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Planta Med 2009; 75(8): 803-807
DOI: 10.1055/s-0029-1185386
Pharmacology
Original Paper
© Georg Thieme Verlag KG Stuttgart · New York

A Peroxisome Proliferator-Activated Receptor-gamma Agonist and Other Constituents from Chromolaena odorata

Nguyen Tien Dat1 , 2 , 3 , Kyeong Lee1 , Young-Soo Hong1 , Young Ho Kim2 , Chau Van Minh3 , Jung Joon Lee1
  • 1Molecular Cancer Research Center, Korean Research Institute of Biosciences and Biotechnology, Daejeon, Korea
  • 2Laboratory of Natural Products, Chungnam National University, Daejeon, Korea
  • 3Laboratory of Organic Chemistry, Institute of Natural Products Chemistry, Vietnam Academy of Sciences and Technology, Hanoi, Vietnam
Further Information

Publication History

received July 21, 2008 revised Dec. 29, 2008

accepted January 18, 2009

Publication Date:
25 February 2009 (online)

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Abstract

Peroxisome proliferator-activated receptors (PPARs) are key regulators of lipid and glucose metabolism and have become important therapeutic targets for various diseases. The phytochemical investigation of the chloroform-soluble extract of Chromolaena odorata led to the isolation of a PPAR-γ agonist, (9S,13R)-12-oxo-phytodienoic acid (1), together with 12 other compounds. The structures of chromomoric acid G (2), a new dehydrogenated derivative of 1, and chromolanone (3) were elucidated based on spectroscopic methods. Compound 1 showed a significant effect on PPAR-γ activation in comparison with rosiglitazone. However, compound 2 was inactive, suggesting that the dehydrogenation of the prostaglandin-like structure in 1 abrogates its PPAR-γ agonistic activity.

Key words

Chromolaena odorata - Asteraceae - (9S,13R)‐12‐oxo‐phytodienoic acid - chromomoric acid G - PPAR‐γ

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Ph.D. Jung Joon Lee

Korean Research Institute of Biosciences and Biotechnology

Deajeon 305-333

Korea

Phone: + 82 42 8 60 43 60

Email: jjlee@kribb.re.kr

    www.thieme-connect.de/ejournals/toc/plantamedica