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DOI: 10.1055/s-0029-1185506
© Georg Thieme Verlag KG Stuttgart · New York
Cytotoxic and Antioxidative Phenolic Compounds from the Traditional Chinese Medicinal Plant, Myristica fragrans
Publikationsverlauf
received August 14, 2008
revised February 13, 2009
accepted February 18, 2009
Publikationsdatum:
26. März 2009 (online)
![](https://www.thieme-connect.de/media/plantamedica/200911/lookinside/thumbnails/10.1055-s-0029-1185506-1.jpg)
Abstract
Two new phenolic compounds were isolated from the fruits of Myristica fragrans and their structures were elucidated as (−)-1-(2,6-dihydroxyphenyl)-9-[4-hydroxy-3-(p-menth-1-en-8-oxy)-phenyl]-1-nonanone (1) and (7R,8R)-7,8-dihydro-7-(3,4-dihydroxyphenyl)-3′-methoxy-8-methyl-1′-(E-propenyl)benzofuran (2). In addition, the absolute configuration of (+)-Δ8′-7-acetoxy-3,4,3′,5′-tetramethoxy-8-O-4′-neolignan (3) was determined for the first time through spectroscopic and chemical methods. Their antioxidative activities against 2,2-diphenyl-1-picrylhydrazyl radical and cytotoxicity against K-562 cells were tested, and (7S,8S,7′R,8′S)-4,5′-dihydroxy-3,3′-dimethoxy-7,7′-epoxylignan (4) showed the corresponding activities with IC50 values of 39.4 and 2.11 µM, respectively.
Key words
Myristica fragrans - Myristicaceae - cytotoxicity - antioxidative activity - phenylpropanoids
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1 These authors equally contributed to this paper.
Prof. Dr. Wei-Ming Zhu
School of Medicine and Pharmacy
Ocean University of China
5# Yushan Road
Qingdao 266003
People's Republic of China
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