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Planta Med 2009; 75(11): 1241-1245
DOI: 10.1055/s-0029-1185506
Natural Product Chemistry
Original Paper
© Georg Thieme Verlag KG Stuttgart · New York

Cytotoxic and Antioxidative Phenolic Compounds from the Traditional Chinese Medicinal Plant, Myristica fragrans

Lin Duan1 [*] , Hong-Wen Tao1 [*] , Xiaojiang Hao2 , Qian-Qun Gu1 , Wei-Ming Zhu1
  • 1Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of , China, Qingdao, P. R. China
  • 2State Key Laboratory of Phytochemistry and Plant Resources, Kunming Institute of Botany, Chinese Academy of , Sciences, Kunming, P. R. China
Further Information

Publication History

received August 14, 2008 revised February 13, 2009

accepted February 18, 2009

Publication Date:
26 March 2009 (online)

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Abstract

Two new phenolic compounds were isolated from the fruits of Myristica fragrans and their structures were elucidated as (−)-1-(2,6-dihydroxyphenyl)-9-[4-hydroxy-3-(p-menth-1-en-8-oxy)-phenyl]-1-nonanone (1) and (7R,8R)-7,8-dihydro-7-(3,4-dihydroxyphenyl)-3′-methoxy-8-methyl-1′-(E-propenyl)benzofuran (2). In addition, the absolute configuration of (+)-Δ8′-7-acetoxy-3,4,3′,5′-tetramethoxy-8-O-4′-neolignan (3) was determined for the first time through spectroscopic and chemical methods. Their antioxidative activities against 2,2-diphenyl-1-picrylhydrazyl radical and cytotoxicity against K-562 cells were tested, and (7S,8S,7′R,8′S)-4,5′-dihydroxy-3,3′-dimethoxy-7,7′-epoxylignan (4) showed the corresponding activities with IC50 values of 39.4 and 2.11 µM, respectively.

Key words

Myristica fragrans - Myristicaceae - cytotoxicity - antioxidative activity - phenylpropanoids

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1 These authors equally contributed to this paper.

Prof. Dr. Wei-Ming Zhu

School of Medicine and Pharmacy
Ocean University of China

5# Yushan Road

Qingdao 266003

People's Republic of China

Phone: + 86 5 32 82 03 12 68

Fax: + 86 5 32 82 03 12 68

Email: weimingzhu@ouc.edu.cn

    www.thieme-connect.de/ejournals/toc/plantamedica