Three New Alkaloids from Galanthus nivalis and Galanthus elwesii

Abstract

Phytochemical studies on Galanthus species resulted in the isolation of three new compounds: 3,3′-O-(3′,3′′-dihydroxybutanoyl)hamayne and 11,3′-O-(3′,3′′-dihydroxybutanoyl)hamayne from G. nivalis and 2-O-(3′-hydroxybutanoyl)lycorine from G. elwesii. Additionally, 3,11-O-(3′,3′′-dihydroxybutanoyl)hamayne, 3,11,3′-O-(3′,3′′,3′′′-trihydroxybutanoyl)hamayne, 8-O-demethylvasconine, tazettine, epimacronine, and ismine from G. nivalis; 2-O-(3′-acetoxybutanoyl)lycorine and incartine from G. elwesii; and hamayne, 11-O-(3′-hydroxybutanoyl)hamayne and lycorine from both species were isolated. Their structures were determined by EI‐MS, HR‐MS, CD, and 1D and 2D NMR (COSY, NOESY, HMQC, and HMBC) experiments.

Key words

Galanthus nivalis - Galanthus elwesii - Amaryllidaceae - alkaloids - 3,3′‐O‐(3′,3′′‐dihydroxybutanoyl)hamayne - 11,3′‐O‐(3′,3′′‐dihydroxybutanoyl)hamayne - 2‐O‐(3′‐hydroxybutanoyl)lycorine

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