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DOI: 10.1055/s-0029-1185746
© Georg Thieme Verlag KG Stuttgart · New York
Two New Spirobiflavonoids from Abies chensiensis with Moderate NO Production Inhibitory Activity
Publikationsverlauf
received February 6, 2009
revised April 9, 2009
accepted April 21, 2009
Publikationsdatum:
04. Juni 2009 (online)
![](https://www.thieme-connect.de/media/plantamedica/200914/lookinside/thumbnails/10.1055-s-0029-1185746-1.jpg)
Abstract
Phytochemical investigation of the aerial parts of Abies chensiensis afforded two new (compounds 2 and 3) and 27 known compounds, including the related compound larixinol (1). The structures of spirobiflavonoids 1–3 were established using 1D and 2D NMR spectroscopic techniques. In addition, the structure of larixinol (1) was confirmed by X-ray crystallographic analysis. Compounds 1–3 were evaluated for inhibitory activities against LPS-induced NO production in macrophages. Larixinol (1) showed moderate effects, with an IC50 value of 60.0 µg/mL. In addition, it did not show any cytotoxicity on RAW 264.7 macrophages at 100 µg/mL.
Key words
Abies chensiensis - Pinaceae - spirobiflavonoids - larixinol - RAW 264.7 macrophages - NO
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Dr. Wei-Dong Zhang
Department of Natural Product Chemistry
School of Pharmacy
Second Military Medical University
325 Guohe Road
Shanghai 200433
People's Republic of China
Telefon: + 86 21 81 87 12 44
Fax: + 86 21 81 87 12 44
eMail: wdzhangy@hotmail.com
Dr. Xian-Wen Yang
Key Laboratory of Marine Bio-resources Sustainable Utilization
South China Sea Institute of Oceanology
Chinese Academy of Sciences
164 West Xingang Road
Guangzhou 510301
People's Republic of China
Telefon: + 86 20 89 02 31 74
Fax: + 86 21 84 45 16 72
eMail: yangxw76@163.com
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