Planta Med 2009; 75(14): 1534-1537
DOI: 10.1055/s-0029-1185746
Natural Product Chemistry
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Two New Spirobiflavonoids from Abies chensiensis with Moderate NO Production Inhibitory Activity

Yong-Li Li1 , Xian-Wen Yang1 , 2 , Su-Mei Li2 , Jian Tang1 , Jun-Mian Tian1 , Xiao-Yang Peng1 , Da-Seng Huang1 , Wei-Dong Zhang1 , 3
  • 1Department of Natural Product Chemistry, School of Pharmacy, Second Military Medical University, Shanghai, P. R. China
  • 2Key Laboratory of Marine Bio-resources Sustainable Utilization, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, P. R. China
  • 3School of Pharmacy, Shanghai Jiao Tong University, Shanghai, P. R. China
Further Information

Publication History

received February 6, 2009 revised April 9, 2009

accepted April 21, 2009

Publication Date:
04 June 2009 (online)

Abstract

Phytochemical investigation of the aerial parts of Abies chensiensis afforded two new (compounds 2 and 3) and 27 known compounds, including the related compound larixinol (1). The structures of spirobiflavonoids 13 were established using 1D and 2D NMR spectroscopic techniques. In addition, the structure of larixinol (1) was confirmed by X-ray crystallographic analysis. Compounds 13 were evaluated for inhibitory activities against LPS-induced NO production in macrophages. Larixinol (1) showed moderate effects, with an IC50 value of 60.0 µg/mL. In addition, it did not show any cytotoxicity on RAW 264.7 macrophages at 100 µg/mL.

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Dr. Wei-Dong Zhang

Department of Natural Product Chemistry
School of Pharmacy
Second Military Medical University

325 Guohe Road

Shanghai 200433

People's Republic of China

Phone: + 86 21 81 87 12 44

Fax: + 86 21 81 87 12 44

Email: wdzhangy@hotmail.com

Dr. Xian-Wen Yang

Key Laboratory of Marine Bio-resources Sustainable Utilization
South China Sea Institute of Oceanology
Chinese Academy of Sciences

164 West Xingang Road

Guangzhou 510301

People's Republic of China

Phone: + 86 20 89 02 31 74

Fax: + 86 21 84 45 16 72

Email: yangxw76@163.com