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DOI: 10.1055/s-0029-1186053
© Georg Thieme Verlag KG Stuttgart · New York
New Secoisolariciresinol Derivatives from Lindera obtusiloba Stems and Their Neuroprotective Activities
Publikationsverlauf
received April 6, 2009
revised July 9, 2009
accepted July 22, 2009
Publikationsdatum:
25. August 2009 (online)
![](https://www.thieme-connect.de/media/plantamedica/201003/lookinside/thumbnails/10.1055-s-0029-1186053-1.jpg)
Abstract
A methanolic extract of Lindera obtusiloba (Lauraceae) stems significantly attenuated glutamate-induced oxidative stress in HT22 hippocampal cells. Two new secoisolariciresinol derivatives, characterized as 9,9′-O-di-(E)-feruloyl-meso-5,5′-dimethoxysecoisolariciresinol (1) and 9,9′-O-di-(E)-sinapinoyl-meso-5,5′-dimethoxysecoisolariciresinol (2), were isolated, along with the known compound 9,9′-O-di-(E)-feruloyl-meso-secoisolariciresinol (3), from the methanolic extract of L. obtusiloba stems. Compounds 1, 2, and 3 showed neuroprotective effects on glutamate-induced toxicity in HT22 cells.
Key words
Lindera obtusiloba - Lauraceae - HT22 hippocampal cells - neuroprotective - lignan
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