Abstract
A methanolic extract of Lindera obtusiloba (Lauraceae) stems significantly attenuated glutamate-induced oxidative stress in HT22 hippocampal cells. Two new secoisolariciresinol derivatives, characterized as 9,9′-O-di-(E)-feruloyl-meso-5,5′-dimethoxysecoisolariciresinol (1) and 9,9′-O-di-(E)-sinapinoyl-meso-5,5′-dimethoxysecoisolariciresinol (2), were isolated, along with the known compound 9,9′-O-di-(E)-feruloyl-meso-secoisolariciresinol (3), from the methanolic extract of L. obtusiloba stems. Compounds 1, 2, and 3 showed neuroprotective effects on glutamate-induced toxicity in HT22 cells.
Key words
Lindera obtusiloba
- Lauraceae - HT22 hippocampal cells - neuroprotective - lignan
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Prof. Sang Hyun Sung
College of Pharmacy and Research Institute of Pharmaceutical Science
Seoul National University
599 Gwanak-ro, Gwanak-gu
151-742 Seoul
Republic of Korea
Telefon: + 82 28 80 78 59
Fax: + 82 28 77 78 59
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