Planta Med 2010; 76(3): 294-297
DOI: 10.1055/s-0029-1186053
Natural Product Chemistry
Letters
© Georg Thieme Verlag KG Stuttgart · New York

New Secoisolariciresinol Derivatives from Lindera obtusiloba Stems and Their Neuroprotective Activities

Ki Yong Lee1 , Soon-Han Kim1 , Eun Ju Jeong1 , Jung Hyun Park1 , Seung Hyun Kim1 , Young Choong Kim1 , Sang Hyun Sung1
  • 1College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Seoul, Republic of Korea
Further Information

Publication History

received April 6, 2009 revised July 9, 2009

accepted July 22, 2009

Publication Date:
25 August 2009 (online)

Abstract

A methanolic extract of Lindera obtusiloba (Lauraceae) stems significantly attenuated glutamate-induced oxidative stress in HT22 hippocampal cells. Two new secoisolariciresinol derivatives, characterized as 9,9′-O-di-(E)-feruloyl-meso-5,5′-dimethoxysecoisolariciresinol (1) and 9,9′-O-di-(E)-sinapinoyl-meso-5,5′-dimethoxysecoisolariciresinol (2), were isolated, along with the known compound 9,9′-O-di-(E)-feruloyl-meso-secoisolariciresinol (3), from the methanolic extract of L. obtusiloba stems. Compounds 1, 2, and 3 showed neuroprotective effects on glutamate-induced toxicity in HT22 cells.

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Prof. Sang Hyun Sung

College of Pharmacy and Research Institute of Pharmaceutical Science
Seoul National University

599 Gwanak-ro, Gwanak-gu

151-742 Seoul

Republic of Korea

Phone: + 82 28 80 78 59

Fax: + 82 28 77 78 59

Email: shsung@snu.ac.kr