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DOI: 10.1055/s-0029-1186160
© Georg Thieme Verlag KG Stuttgart · New York
Three Major Metabolites of Mulberroside A in Rat Intestinal Contents and Feces
Publikationsverlauf
received May 2, 2009
revised August 18, 2009
accepted August 25, 2009
Publikationsdatum:
28. September 2009 (online)
![](https://www.thieme-connect.de/media/plantamedica/201004/lookinside/thumbnails/10.1055-s-0029-1186160-1.jpg)
Abstract
Mulberroside A, a major stilbene constituent of Morus alba L. (Moraceae), displays significant antitussive and antiasthmatic effects in animals. As part of our ongoing research on its biotransformation in rats, mulberroside A was orally administered to rats, and the metabolites in the gastrointestinal contents and feces were investigated. Three major metabolites were isolated from the feces of rats and identified as oxyresveratrol-2-O-β-D-glucopyranoside (1), oxyresveratrol-3′-O-β-D-glucopyranoside (2), and oxyresveratrol (3) on the basis of chemical and spectroscopic evidence. The three metabolites were also detected in the small intestinal contents of rats following oral administration of mulberroside A. These findings suggest that mulberroside A is metabolized prior to absorption into the body.
Key words
Moraceae - Morus alba - mulberroside A - metabolites - gastrointestinal contents - feces
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1 These authors contributed equally to this work.
Prof. Feng Qiu
Department of Natural Products Chemistry
Shenyang Pharmaceutical University
103 Wenhua Road
Shenyang 110016
Liaoning
People's Republic of China
Telefon: + 86 24 23 98 64 63
Fax: + 86 24 23 99 39 94
eMail: fengqiu2000@tom.com
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