Planta Med 2010; 76(4): 362-364
DOI: 10.1055/s-0029-1186160
Natural Product Chemistry
Letters
© Georg Thieme Verlag KG Stuttgart · New York

Three Major Metabolites of Mulberroside A in Rat Intestinal Contents and Feces

Meicuo Zhaxi1 [*] , Lixia Chen1 [*] , Xuegai Li1 , Kenichi Komatsu2 , Xinsheng Yao1 , Feng Qiu1
  • 1Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Shenyang, Liaoning, P. R. China
  • 2Department of Kampo Medicinal Science, Hokkaido College of Pharmacy, Otaru, Japan
Further Information

Publication History

received May 2, 2009 revised August 18, 2009

accepted August 25, 2009

Publication Date:
28 September 2009 (online)

Abstract

Mulberroside A, a major stilbene constituent of Morus alba L. (Moraceae), displays significant antitussive and antiasthmatic effects in animals. As part of our ongoing research on its biotransformation in rats, mulberroside A was orally administered to rats, and the metabolites in the gastrointestinal contents and feces were investigated. Three major metabolites were isolated from the feces of rats and identified as oxyresveratrol-2-O-β-D-glucopyranoside (1), oxyresveratrol-3′-O-β-D-glucopyranoside (2), and oxyresveratrol (3) on the basis of chemical and spectroscopic evidence. The three metabolites were also detected in the small intestinal contents of rats following oral administration of mulberroside A. These findings suggest that mulberroside A is metabolized prior to absorption into the body.

References

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  • 3 Kan Q M, Kang N, Tian H T, Li C L, Qiu F, Liu Y L. Antitussive and antiasthmatic effects of mulberroside A.  Shenyang Yaoke Daxue Xuebao. 2006;  23 388-391
  • 4 Qiu F, Komatsu K I, Saito K I, Kawasaki K, Yao X S, KanoY. Pharmacological properties of traditional medicines. XXII. Pharmacokinetic study of mulberroside A and its metabolites in rat.  Biol Pharm Bull. 1996;  19 1463-1467
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  • 7 Qiu F, Kenichi K, Kanako K, Kenichi S, Yao X S, Yonshihiro K. A novel stilbene glucoside, oxyresveratrol 3′-β-O-glucopyranoside, from the root bark of Morus alba.  Planta Med. 1996;  62 559-561
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1 These authors contributed equally to this work.

Prof. Feng Qiu

Department of Natural Products Chemistry
Shenyang Pharmaceutical University

103 Wenhua Road

Shenyang 110016

Liaoning

People's Republic of China

Phone: + 86 24 23 98 64 63

Fax: + 86 24 23 99 39 94

Email: fengqiu2000@tom.com