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Exp Clin Endocrinol Diabetes 1991; 97(2/03): 153-159
DOI: 10.1055/s-0029-1211055
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© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

The TSH Receptor in Autoimmune Basedow's Disease

T. Akamizu, M. Saji, S. Ikuyama, S. Kosugi, K. Tahara, L. D. Kohn
  • Section on Cell Regulation, Laboratory of Biochemistry and Metabolism, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda/USA
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Publication Date:
16 July 2009 (online)

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Summary

The cloning approaches of the past two years have opened new doors to the pursuit of our understanding Basedow's disease. The cloning of the TSH receptor is the most dramatic step; nevertheless, all the proteins mentioned in the following appear to be important molecules in the bioactivity of the thyroid cell and are implicated as autoantigens.