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Exp Clin Endocrinol Diabetes 1996; 104: 87-88
DOI: 10.1055/s-0029-1211565
Part III — Posters
Receptor Structure and Function
© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

P-22: Conflicting activities of peptide analogues of the C and D domains of IGF-1 (JB-1 and JB-2)

D. R. Hodgson, M. R. Daws, J. Grayaa , F. E. B. May, B. R. Westley
  • University Department of Pathology, Royal Victoria Infirmary, Newcastle Upon Tyne, NE1 4LP
  • aCentral Facility for Molecular Biology, Medical School, Newcastle Upon Tyne, NE2 4HH
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Publication History

Publication Date:
15 July 2009 (online)

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Summary

We have demonstrated that the peptides JB-1 and JB-23 do not inhibit the binding of IGF-1 to the type I IGF receptor and IGFBP. The peptides do, however, inhibit IGF-1 induced phosphorylation of the type I IGF receptor. Clearly this is not due to an inhibitory effect on the binding of IGF-1 to the receptor and the mechanism underlying the antagonist effect of the peptides on receptor phosphorylation remains unclear.