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Synthesis 2010(3): 538-542
DOI: 10.1055/s-0029-1217102
DOI: 10.1055/s-0029-1217102
PSP
© Georg Thieme Verlag
Stuttgart ˙ New York
A Practical Method for O-Acylation of N-Hydroxythiazole-2(3H)-thiones
Weitere Informationen
Received
24 July 2009
Publikationsdatum:
06. November 2009 (online)
Publikationsverlauf
Publikationsdatum:
06. November 2009 (online)
![](https://www.thieme-connect.de/media/synthesis/201003/lookinside/thumbnails/10.1055-s-0029-1217102-1.jpg)
Abstract
O-Acylation of 4- and 4,5-substituted N-hydroxythiazole-2(3H)-thiones occurred in solutions of acetone upon treatment with solid K2CO3 and a variety of neat acyl chlorides (primary, secondary, and tertiary alkyl, aryl; 60-87% yield; ∼10 g scale).
Key words
anhydride - acyl chloride - carbon radical - thiazolethione - thiohydroxamic acid
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