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Synfacts 2009(7): 0703-0703  
DOI: 10.1055/s-0029-1217242
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Nakiterpiosin

Contributor(s): Philip Kocienski
S. Gao, Q. Wang, C. Chen*
The University of Texas Southwestern Medical Center at Dallas, USA
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Publication History

Publication Date:
22 June 2009 (online)

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Significance

The synthesis of nakiterpiosin, a cytotoxic sponge metabolite, features a Pd-­catalyzed carbonylative cross-coupling (K → L) followed by a photo-Nazarov cyclization (L → M) to create the indanone moiety.