Synlett 2009(12): 2010-2016  
DOI: 10.1055/s-0029-1217535
LETTER
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Polycyclic Indolone and Pyrroloindolone Heterocycles via the Annulation of Indole- and Pyrrole-2-Carboxylate Esters with Arynes

Robert D. Giacometti, Yeeman K. Ramtohul*
Department of Medicinal Chemistry, Merck Frosst Centre for Therapeutic Research, Merck Frosst Canada Ltd., P.O. Box 1005, 16711 Trans Canada Highway, Kirkland, Quebec, H9H 3L1, Canada
Fax: +1(514)4284900; e-Mail: yeeman_ramtohul@merck.com;
Further Information

Publication History

Received 8 April 2009
Publication Date:
01 July 2009 (online)

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Abstract

A mild and general method for the synthesis of a variety of polycyclic indolone and pyrroloindolone heterocycles via the reaction of indole- and pyrrole-2-carboxylate esters with arynes has been developed.