Abstract
Our work shows how poly(ethylene glycol), differentially functionalized
at two ends, can be easily and efficiently synthesized from commercial
symmetric dihydroxy PEG 600. First, we linked the polymer onto functionalized
silica gel using one of its hydroxy ends. Then, the second
hydroxy group was modified, and finally, the desymmetrized PEG was
cleaved from the solid support.
Key words
desymmetrization - mono protection - poly(ethylene glycol)
polymer - solid phase
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