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DOI: 10.1055/s-0029-1217740
A Facile Access to Antiflu Agent Tamiflu/Oseltamivir
Publikationsverlauf
Publikationsdatum:
27. August 2009 (online)

Abstract
A practical approach to Tamiflu is developed featuring the construction of the carbocycle core of the target molecule through a Diels-Alder reaction with concurrent introduction of one of the nitrogen atoms. Incorporation of another nitrogen atom was achieved via a high-yielding regioselective ring opening of a cyclic sulfite.
Key words
Diels-Alder reactions - eliminations - enantiomeric resolution - epoxides - antiviral agents
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- Supporting Information
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References and Notes
Information about avian flu and H5N1 virus can be found in: http://www.nature.com/avianflu/index.html.
13The absolute configuration of (+)-10 was established by comparison of the spectroscopic data of the 15 thus derived with those reported in the literature (ref. 2k).