Acetic Anhydride (Ac₂O)

Introduction

Acetic anhydride (Ac₂O) is a very refractive liquid smelling strongly of acetic acid with a boiling point at 139 ˚C. [¹] It is a cheap and commercialized reagent widely used in the synthesis of oxazolones, [²] thiohydantoins, [³] thioacetates, [4] enamides, [5] geminal diacetates, [6] thiadiazoles, [7] as well as in the preparation of carbonyl compounds from imines. [8] Further, it is used in acetylations, [9] brominations, [¹0] Grignard reactions, [¹¹] and reductive acylations of nitropyrroles. [¹²]

References

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