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Synfacts 2009(10): 1060-1060  
DOI: 10.1055/s-0029-1217858
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of BMS-317180

Contributor(s): Philip Kocienski
A. H. Davulcu*, D. D. McLeod, J. Li, K. Katipally, A. Littke, W. Doubleday, Z. Xu, C. W. McConlogue, C. J. Lai, M. Gleeson, M. Schwinden, R. L. Parsons Jr.*
Bristol-Myers Squibb Company, New Brunswick, USA
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Publication History

Publication Date:
22 September 2009 (online)

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Significance

Many of the health problems that beset the elderly may be due to deficiency in the human growth hormone (hGH) that results in ­neuroendocrine dysregulation. BMS-317180 is an orally active growth hormone secretagogue receptor agonist that has advanced into clinical ­development. The synthesis shown delivered BMS-317180 on a multi-kilogram scale.