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Synfacts 2009(10): 1139-1139  
DOI: 10.1055/s-0029-1217895
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Functional Group Tolerant Kumada-Corriu-Tamao Coupling

Contributor(s): Paul Knochel, Tobias Thaler
O. Vechorkin, V. Proust, X. Hu*
Ecole Polytechnique Fédérale de Lausanne, Switzerland
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Publikationsdatum:
22. September 2009 (online)

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Significance

The nickel(II) pincer complex 1 could be successfully used to promote a range of Kumada-Corriu-Tamao couplings using both functionalized organomagnesium reagents and alkyl iodides/bromides. Sensitive functional groups, such as ester, cyano, amide, and CF3 were well tolerated.