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Synlett 2009(17): 2825-2827  
DOI: 10.1055/s-0029-1217995
LETTER
© Georg Thieme Verlag Stuttgart ˙ New York

A Simple One-Pot Synthesis of 2-Aryl-5-alkyl-Substituted Oxazoles by Cs2CO3-Mediated Reactions of Aromatic Primary Amides with 2,3-Dibromopropene

Nasima Yasmin, Jayanta K. Ray*
Department of Chemistry, Indian Institute of Technology, Kharagpur-721302, India
e-Mail: jkray@chem.iitkgp.ernet.in;
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Publikationsverlauf

Received 29 May 2009
Publikationsdatum:
30. September 2009 (online)

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Abstract

A simple and efficient method for the synthesis of 2-aryl-5-alkyl-substituted oxazoles has been developed. A series of 2,5-disubstituted oxazoles were synthesized in a single step by Cs2CO3-mediated reactions of aromatic primary amides with 2,3-dibromopropene.

Key words

substituted oxazole - aromatic primary amide - 2,3-dibromopropene - cesium carbonate - dimethylsulfoxide

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