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Synlett 2009(20): 3299-3302
DOI: 10.1055/s-0029-1218377
DOI: 10.1055/s-0029-1218377
LETTER
© Georg Thieme Verlag
Stuttgart ˙ New York
Synthesis of N-Substituted 2-Fluoromethylbenzimidazoles via Bis(trifluoroacetoxy)iodobenzene-Mediated Intramolecular Cyclization of N,N′-Disubstituted Fluoroethanimidamides
Weitere Informationen
Received
18 September 2009
Publikationsdatum:
18. November 2009 (online)
Publikationsverlauf
Publikationsdatum:
18. November 2009 (online)
![](https://www.thieme-connect.de/media/synlett/200920/lookinside/thumbnails/10.1055-s-0029-1218377-1.jpg)
Abstract
A mild and efficient method for the synthesis of N-substituted 2-fluoromethylbenzimidazoles via [bis(trifluoroacetoxy)-iodo]benzene-mediated intramolecular cyclization of N,N′-disubstituted bromodifluoro (or trifluoro) ethanimidamides was described.
Key words
fluoroethanimidamides - benzimidazoles - BTI - oxidative coupling
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