Efficient Synthesis of Azaspirodienones
by Microwave-Assisted Radical Spirocyclization of Xanthate-Containing
Ugi Adducts

Rocío Gámez-Montaño; Tannya Ibarra-Rivera; Laurent El Kaïm; Luis D. Miranda

doi:10.1055/s-0029-1218700

PAPER

Efficient Synthesis of Azaspirodienones by Microwave-Assisted Radical Spirocyclization of Xanthate-Containing Ugi Adducts

Rocío Gámez-Montaño*^a, Tannya Ibarra-Rivera^a, Laurent El Kaïm^b, Luis D. Miranda^c
^a Departamento de Química, Universidad de Guanajuato, Noria Alta S/N, 36050 Guanajuato, Gto., Mexico
Fax: +52(473)73200068168; e-Mail: rociogm@quijote.ugto.mx;
^b Laboratoire Chimie et Procédés, DCSO, UMR 7652, and Ecole Nationale Supérieure de Techniques Avancées, 32 Bd Victor, 75015 Paris, France
^c Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Coyoacán, 04510 México, D. F., Mexico

Abstract

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Abstract

The sequential use of an Ugi reaction and radical spirocyclization under microwave irradiation conditions is described. The process provides rapid access to spirodienone lactams.

Key words

Ugi reaction - cyclizations - spiro compounds - lactams - microwave reactions

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