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Synthesis 2010(8): 1285-1290
DOI: 10.1055/s-0029-1218700
DOI: 10.1055/s-0029-1218700
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
Efficient Synthesis of Azaspirodienones by Microwave-Assisted Radical Spirocyclization of Xanthate-Containing Ugi Adducts
Further Information
Received
22 August 2009
Publication Date:
12 March 2010 (online)
Publication History
Publication Date:
12 March 2010 (online)
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Abstract
The sequential use of an Ugi reaction and radical spirocyclization under microwave irradiation conditions is described. The process provides rapid access to spirodienone lactams.
Key words
Ugi reaction - cyclizations - spiro compounds - lactams - microwave reactions
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References
Microwave reactions were conducted using a CEM Discover Synthesis™ Unit (CEM Corp., Matthews, NC); see: http://www.cem.com/page176.html.