Three-Component One-Pot Synthesis
of 3-(2-Furanyl)indoles from Acetylenedicarboxylate, Isocyanide,
and 3-Formylindole

B. V. Subba Reddy; A. Mallikarjun Reddy; D. Somashekar; J. S. Yadav; B. Sridhar

doi:10.1055/s-0029-1218824

PAPER

Three-Component One-Pot Synthesis of 3-(2-Furanyl)indoles from Acetylenedicarboxylate, Isocyanide, and 3-Formylindole

B. V. Subba Reddy*^a, A. Mallikarjun Reddy^a, D. Somashekar^a, J. S. Yadav^a, B. Sridhar^b
^a Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 007, India
^b Centre for X-ray Crystallography, Indian Institute of Chemical Technology, Hyderabad 500 007, India
e-Mail: basireddy@iict.res.in;

Abstract

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Abstract

The zwitterions derived from isocyanide and dimethyl acetylenedicarboxylate undergo smooth condensation with 3-formylindoles in benzene at room temperature to give the corresponding 3-(2-furanyl)indoles in good yields. This method provides a simple and convenient route to produce a wide range of 3-heteroarylindoles in a one-pot operation.

Key words

3-formylindoles - isocyanides - DMAD - zwitterions - 3-furanylindoles

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References

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