9-Amino-9-Deoxyepicinchona Alkaloids

Introduction

9-Amino-9-deoxyepicinchona alkaloids constitute the newest generation of the family of cinchona alkaloids. The last few years have witnessed a special interest in this kind of cinchona alkaloids derivatives. [¹] As bifunctional organocatalysts combine a Brønsted acid and Lewis base in one molecule, they are capable of promoting many asymmetric reactions and provide access to chiral building blocks of high enantiopurity. In addition, they can be easily prepared in one pot from inexpensive alkaloid starting materials in either of pseudo-enantiomeric forms (Scheme  [¹] ). [²]

Scheme 1

References

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