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Synlett 2010(3): 475-479
DOI: 10.1055/s-0029-1219173
DOI: 10.1055/s-0029-1219173
LETTER
© Georg Thieme Verlag
Stuttgart ˙ New York
The First Cobalt-Catalyzed Transformation of Alkynyl C-H Bond: Aldehyde-Alkyne-Amine (A³) Coupling
Further Information
Received
25 September 2009
Publication Date:
07 January 2010 (online)
Publication History
Publication Date:
07 January 2010 (online)
Abstract
The first highly effective cobalt-catalyzed reaction of terminal alkynes was developed. The reaction of alkynes with aldehyde and amine generated a diverse range of propargyl amines in excellent yields by this method.
Key words
cobalt-catalyzed - aldehyde-alkyne-amine coupling - A³ coupling - alkynyl C-H activation
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