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Synlett 2010(3): 501-502
DOI: 10.1055/s-0029-1219338
DOI: 10.1055/s-0029-1219338
SPOTLIGHT
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Ethyl 2-Cyano-3,3-bis(methylthio)acrylate
Further Information
Publication History
Publication Date:
25 January 2010 (online)
Introduction
Ethyl 2-cyano-3,3-bis(methylthio)acrylate (Figure [¹] ) was prepared by the reaction of ethyl cyanoacetate, carbon disulfide and dimethyl sufate in the presence of a base. [¹] Gommper and co-workers studied this reaction thoroughly. The electron-attracting groups on C2 makes it a very useful reagent for the preparation of heterocyclic compounds. [²] Moreover, Ethyl 2-cyano-3,3-bis(methylthio)acrylate can also be prepared efficiently using sodium ethoxide as a base. [³] In the literature numerous reports appeared highlighting its chemistry and use.
Figure 1 Ethyl 2-Cyano-3,3-bis(methylthio)acrylate
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