Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000083.xml
Synlett 2010(7): 1101-1103
DOI: 10.1055/s-0029-1219796
DOI: 10.1055/s-0029-1219796
LETTER
© Georg Thieme Verlag
Stuttgart ˙ New York
Tributyltin Hydride in NMP-Promoted Reduction of Acid Chlorides to Aldehydes under Transition-Metal-Free Conditions
Further Information
Publication History
Received
17 December 2009
Publication Date:
23 March 2010 (online)


Abstract
Tributyltin hydride in N-methyl-2-pyrrolidinone (NMP) was used for the partial reduction of various functionalized acid chlorides at room temperature. This transition-metal-free procedure allows the synthesis of a range of (hetero)aromatic- and aliphatic aldehydes in good to excellent yields.
Key words
acid chlorides - aldehydes - reduction - tributyltin hydride - N-methyl-2-pyrrolidinone - free-metal conditions