Synlett 2010(9): 1331-1332  
DOI: 10.1055/s-0029-1219826
LETTER
© Georg Thieme Verlag Stuttgart ˙ New York

Selective C-tert-Butoxycarbonylation Using Di-tert-butyl Dicarbonate for the Synthesis of Multifunctional Carbon Compounds

Piétrick Hudhomme*
Université d’Angers, CNRS UMR 6200, Institut des Sciences et Technologies Moléculaires d’Angers Moltech Anjou, 2 Boulevard Lavoisier, 49045 Angers, France
Fax: +33(2)41735405; e-Mail: pietrick.hudhomme@univ-angers.fr;
Further Information

Publication History

Received 22 February 2010
Publication Date:
15 April 2010 (online)

Abstract

The reaction of di-tert-butyl dicarbonate (Boc2O) in the presence of the acylation catalyst 4-dimethylaminopyridine (DMAP) was examined with N-Boc or N-acyl cyanoglycinate. The couple Boc2O/DMAP was found to act as an efficient agent for ­selective C-tert-butoxycarbonylation affording multifunctional carbon compounds.