Subscribe to RSS
DOI: 10.1055/s-0029-1220939
© Georg Thieme Verlag KG Stuttgart · New York
Clear Cell Meningeoma of the Brainstem in a 3.5-year-old Child: Case Report and Review of the Literature
Publication History
Publication Date:
14 April 2010 (online)
![](https://www.thieme-connect.de/media/zblneurochir/201003/lookinside/thumbnails/10.1055-s-0029-1220939-1.jpg)
Introduction
Meningiomas are benign neoplasms of meningeal origin. Meningiomas constitute approximately 20% of all intracranial tumors and occur predominantly during the 5th and 6th decades of life [1]. Childhood and adolescence meningiomas are relatively rare and must be considered individually, as they have different features to adult meningiomas. Congenital meningiomas diagnosed in infancy are even rarer.
Pediatric meningiomas make up 1–2.8% of all meningiomas and 0.4–4.1% of all intracranial pediatric tumors. In children, meningiomas tend to grow rapidly, undergo malignant changes, and are likely to recur. The prognosis in children is poor.
References
- 1 Abdulrauf SI, Al-Mefty O. Intracranial meningioma; in Batjer HH, Loftus CM (eds). Textbook of Neurological Surgery. Philadelphia, Lippincott/Williams & Wilkins; 2003. vol. 2 pp 1303-1311
- 2 Al-Mefty O, Topsakal C, Pravdenkova S. et al . Radiation-induced meningiomas: clinical, pathological, cytokinetic, and cytogenetic characteristics. J Neurosurg. 2004; 100 1002-1013
- 3 Amirjamshidi A, Mehrazin M, Abbassioun K. Meningiomas of the central nervous system occurring below the age of 17: Report of 24 cases not associated with neurofibromatosis and review of literature. Childs Nerv Syst. 2000; 16 406-416
- 4 Baumgartner JE, Sorenson JM. Meningioma in the pediatric population. J Neurooncol. 1996; 29 223-228
- 5 Begnami MD, Rushing EJ, Santi M. et al . Evaluation of NF2 gene deletion in pediatric meningiomas using chromogenic in situ hybridization. Int J Surg Pathol. 2007; 15 (2) 110-115
- 6 Carra S, Drigo P, Gardiman M. et al . Clear cell meningioma in a 22-month-old male: a case report and literature review. Pediatr Neurosurg. 2001; 34 264-267
- 7 Chan RC, Thompson GB. Morbidity, mortality, and quality of life following surgery for intracranial meningiomas: A retrospective study in 257 cases. J Neurosurg. 1984; 60 52-60
- 8 Darling CF, Byrd SE, Reyes-Mugica M. et al . MR of pediatric intracranial meningiomas. AJNR Am Neuroradiol. 1994; 15 (3) 435-440
- 9 Davidson GS, Hope JK. Meningeal tumors of childhood. Cancer. 1989; 63 1205-1210
- 10 Deen Jr HG, Scheithauer BW, Ebersold MJ. Clinical and pathological study of meningiomas of the first two decades of life. J Neurosurg. 1982; 56 317-322
- 11 Demirtas E, Ersahin Y, Yilmaz F. et al . Intracranial meningeal tumours in childhood: A clinicopathologic study including MIB-1 immunohistochemistry. Pathol Res Pract. 2000; 196 151-158
- 12 Di Rocco C, Di Rienzo A. Meningiomas in childhood. Crit Rev Neurosurg. 1999; 9 180-188
- 13 Erdinçler P, Lena G, Sanoglu AC. et al . Intercranial meningiomas in children: review of 29 cases. Surg Neurol. 1998; 49 136-141
- 14 Ferrante L, Acqui M, Artico M. et al . Paediatric intracranial meningiomas. Br J Neurosurg. 1989; 3 189-190
- 15 Germano IM, Edwards MSB, Davis RL. et al . Intracranial meningiomas of the first two decades of life. J Neurosurg. 1994; 80 447-453
- 16 Ghim TT, Seo JJ, O’Brien M. et al . Childhood intracranial meningiomas after high-dose irradiation. Cancer. 1993; 71 4091-4095
- 17 Glasier CM, Husain MM, Chadduck W. et al . Meningiomas in children: MR and histopathologic findings. AJNR. 1993; 14 237-241
- 18 Goldsmith BJ, Wara WM, Wilson CB. et al . Postoperative irradiation for subtotally resected meningiomas: a retrospective analysis of 140 patients treated from 1967 to 1990. J Neurosurg. 1994; 80 195-201
- 19 Kantar M, Çetingül N, Kansoy S. et al . Radiotherapy-induced secondary cranial neoplasms in children. Childs Nerv Syst. 2004; 20 46-49
- 20 Mallucci CL, Parkes SE, Barber P. et al . Pediatric meningeal tumours. Child's Nerv Syst. 1996; 12 582-589
- 21 MacCarthy BJ, Davis FG, Freels S. et al . Factors associated with survival in patients with meningioma. J Neurosurg. 1998; 88 831-839
- 22 Mirimanoff RO, Dosoretz DE, Lingood RM. Meningioma: analysis of recurrence and progression following neurosurgical resection. J Neurosurg. 1985; 62 18-24
- 23 Molleston MC, Moran CJ, Roth KA. et al . Infantile meningioma. Pediatr Neurosurg. 1994; 21 195-200
- 24 Moss SD, Rockswold GL, Chou SN. et al . Radiation-induced meningiomas in pediatric patients. Neurosurgery. 1988; 22 758-761
- 25 Numaguchi Y, Hoffman JC, O’Brien MS. et al . Meningiomas in childhood and adolescence. Neurologia medico-chirurgica. 1978; 18 (1) 119-127
- 26 Nunes F, MacCollin M. Neurofibromatosis 2 in the pediatric population. J Child Neurol. 2003; 18 718-724
- 27 Perilongo G, Sutton LN, Goldwein JW. et al . Childhood meningiomas: experience in the modern imaging era. Pediatr Neurosurg. 1992; 18 (1) 16-23
- 28 Perry A, Giannini C, Raghavan R. et al . Aggressive phenotypic and genotypic features in pediatric and NF2-associated meningiomas: a clinicopathologic study of 53 cases. J Neuropathol Exp Neurol. 2001; 60 994-1003
- 29 Ruggieri M, Iannetti P, Polizzi A. et al . Earliest clinical manifestations and natural history of neurofibromatosis type 2 (NF2) in childhood: a study of 24 patients. Neuropediatrics. 2005; 36 21-34
- 30 Rushing EJ, Olsen C, Mena H. et al . Central nervous system meningiomas in the first two decades of life: a clinicopathological analysis of 87 patients. J Neurosurg. (6 Suppl Pediatrics) 2005; 103 489-495
- 31 Sadetzki S, Flint-Richter P, Ben-Tal T. et al . Radiation-induced meningioma: A descriptive study of 253 cases. J Neurosurg. 2002; 97 1078-1082
- 32 Sano K, Wakai S, Ochiai C. et al . Characteristics of intracranial meningiomas in childhood. Childs Brain. 1981; 8 98-106
- 33 Sharif S, Brennan P, Rawluk D. Non-surgical treatment of meningioma: A case report and review. Br J Neurosurg. 1998; 12 369-372
- 34 Sheikh BY, Siqueira E, Dayel F. Meningioma in children: a report of nine cases and review of the literature. Surg Neurol. 1996; 45 328-335
- 35 Stettner GM, Rostasy KM, Ludwig HC. et al . Infratentorial meningioma in an 8-year-old child as first sign of neurofibromatosis type 2. Neuropediatrics. 2007; 38 29-31
- 36 Teo JG, Goh KY, Rosenblum MK. et al . Intraparenchymal clear cell meningioma of the brainstem in a 2-year-old child. Case report and literature review. Pediatr Neurosurg. 1998; 28 27-30
- 37 Tufan K, Dogulu F, Kurta G. et al . Intracranial meningiomas of childhood and adolescence. Pediatr Neurosurg. 2005; 41 1-7
- 38 Turgut M, Oezcan OE, Bertan V. Meningiomas in childhood and adolescence: a report of 13 cases and review of the literature. Br J Neurosurg. 1997; 11 (6) 501-507
- 39 Zorludemir S, Scheithauer BW, Hirose T. et al . Clear cell meningioma. A clinicopathologic study of a potentially aggressive variant of meningioma. Am J Surg Pathol. 1995; 19 493-505
- 40 Zwerdling T, Dothage J. Meningiomas in children and adolescents. J Pediatr Hematol Oncol. 2002; 24 199-204
Correspondence
Dr. H. Taha
Klinikum Solingen, Klinik für Neurochirurgie,
Gotenstraße 1, 42653 Solingen, Germany
Phone: 02/125/47 24 71
Fax: 02/125/47 22 29
Email: drhtaha@gmx.de