Pfefferminzöl beim Reizdarmsyndrom – ein Update

Zusammenfassung

Neuere Untersuchungen bestätigen, dass Pfefferminzöl eine sinnvolle Option in der Therapie des Reizdarmsyndroms ist. Die spasmolytische Wirkung des Pfefferminzöls konnte sowohl in vitro an isolierten Darmsegmenten als auch in vivo an gesunden Probanden und in der Diagnostik des Gastrointestinaltrakts gezeigt werden. Die Hauptkomponente des Öls, Menthol, trägt wesentlich zu seiner spasmolytischen Wirkung bei. In der Behandlung des Reizdarmsyndroms war Pfefferminzöl in kurz- und mittelfristigen klinischen Studien Placebo überlegen.

Summary

Peppermint oil in the treatment of irritable bowel syndrome. An update

Recent investigations confirm that the essential oil of peppermint is a reasonable therapeutic option in the treatment of irritable bowel syndrome. Spasmolytic effects of the essential oil have been demonstrated both in vitro on isolated gut segments and in vivo on healthy voluteers and in gastrointestinal diagnosis. Menthol, the main component of peppermint oil, contributes considerably to its spasmolytic effect. Peppermint oil proved to be superior to a placebo in the treatment of irritable bowel syndrome in short-term and medium-term studies.

Schlüsselwörter

Mentha x piperita L. - Pfefferminze - ätherisches Öl - Übersicht - Reizdarmsyndrom

Key words

Mentha x piperita L. - peppermint - essential oil - review - irritable bowel syndrome

Literatur

• 1 Adam B, Liebregts T, Best J, et al.. A combination of peppermint oil and caraway oil attenuates the post-inflammatory visceral hyperalgesia in a rat model.  Scan J Gastroenterol. 2006;  41 155-160
• 2 Behrends M, Beiderlinden M, Peters J. Acute lung injury after peppermint oil injection.  Anesth Analg. 2005;  101 1160-1162
• 3 Capanni M, Surrenti E, Biagini MR, et al.. Studio randomizzato e controllato per la valutazione dell’olio di menta nel trattamento della sindrome da colon irritabile.  Gazz Med Ital – Arch Sci Med. 2005;  164 119-126
• 4 Capello G, Spezzaferro M, Grossi L, et al.. Peppermint oil (Mintoil^®) in the treatment of irritable bowel syndrome: A prospective double blind placebo-controlled randomized trial.  Digestive Liver Disease. 2007;  39 530-536
• 5 Committee on Herbal Medicinal Products (HMPC) .Public statement on the use of herbal medicinal products containing pulegone and menthofuran. EMEA/HMPC/138386/2005.  http://www.emea.europa.eu/pdfs/human/hmpc/13838605en.pdf; Stand: 11.05.2009
• 6 .Community Herbal Monograph on Mentha x piperita L., Aetheroleum. EMEA/HPMC/349466/2006.  http://www.emea.europa.eu/pdfs/human/hmpc/menthae_piperitae_aetheroleum/34946606enfin.pdf; Stand: 11.05.2009
• 7 ESCOP .Menthae piperitae folium. In: ESCOP Monographs, 2. Aufl. Stuttgart; Thieme 2003
• 8 Ford AC, Talley NJ, Spiegel BMR, et al.. Effect of fibre, antispasmodics, and peppermint oil in the treatment of irritable bowel syndrome: systematic review and meta-analysis.  BMJ. 2008;  337 a2313
• 9 Grigoleit HG, Grigoleit P. Gastrointestinal clinical pharmacology of peppermint oil.  Phytomedicine. 2005;  12 607-611
• 10 Grigoleit HG, Grigoleit P. Pharmacology and preclinical pharmacokinetics of peppermint oil.  Phytomedicine. 2005;  12 612-616
• 11 Hänsel R, Sticher O, Steinegger E. Pharmakognosie – Phytopharmazie. Berlin; Springer 1999
• 12 Hungin AP, Chang L, Locke GR, et al.. Irritable bowel syndrome in the United States: prevalence, symptom patterns and impact.  Aliment Pharmacol Ther. 2005;  21 1365-1375
• 13 Hürlimann R, Stenz V. Gastroenterologie: Die Wiederauferstehung Roms.  Schweiz Med Forum. 2006;  6 1155-1157 ,  http://www.medicalforum.ch/pdf/pdf_d/2006/2006-51/2006-51-290.PDF; Stand: 06.03.2009
• 14 Inamori M, Akiyama T, Akimoto K, et al.. Early effects of peppermint oil on gastric emptying: a crossover study using a continuous real-time ¹³C breath test (BreathID system).  J Gastroenterol. 2007;  42 539-542
• 15 Jones R. Treatment of irritable bowel syndrome in primary care [editorial].  BMJ. 2008;  337 a2213
• 16 Mizuno S, Kato K, Ono Y, et al.. Oral peppermint oil is a useful antispasmodic for doublecontrast barium meal examination.  J Gastroenterol Hepatol. 2006;  21 1297-1301
• 17 .National Institute for Health and Clinical Excellence, ed. Irritable bowel syndrome in adults: Diagnosis and management of irritable bowel syndrome in primary care. NICE clinical guideline 61; Issue date: February 2008 http://www.nice.org.uk/nicemedia/pdf/CG061NICEGuideline.pdf; Stand: 17.02.2009
• 18 Nomoto Y, Yoshida A, Ikeda S, et al.. Effect of menthol on detrusor smooth-muscle contraction and the micturition reflex in rats.  Urology. 2008;  72 701-705
• 19 Pittler MH, Ernst E. Peppermint oil for irritable bowel syndrome: a critical review and metaanalysis.  Am J Gastroenterol. 1998;  93 1131-1135
• 20 Schulz V, Hänsel R. Rationale Phytotherapie. Berlin; Springer 2004
• 21 Spichiger M, Brenneisen R, Felix R, et al.. The inhibition of bone resorption in rats treated with (–)-menthol is due to its metabolites.  Planta Med. 2006;  72 1290-1295
• 22 van Rensen I. Mentha x piperita L. – die Pfefferminze bei Verdauungsbeschwerden.  Z Phytother. 2004;  25 118-127
• 23 Yamamoto N, Nakai Y, Sasahira N, et al.. Efficacy of peppermint oil as an antispasmodic during endoscopic retrograde cholangiopancreatography.  J Gastroenterol Hepatol. 2006;  21 1394-1398

1 einbezogen in statistische Metaanalyse (8);

2 vs. Stress-Management-Therapie;

3 28–56 d Follow up;

4 Gastrointestinal Symptom Rating Scale