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DOI: 10.1055/s-0029-1231085
© Hippokrates Verlag in MVS Medizinverlage Stuttgart GmbH & Co. KG
Ecballium elaterium (L.) A. Rich. – die Eselsgurke
Publikationsverlauf
Publikationsdatum:
03. Juli 2009 (online)

Zusammenfassung
Ecballium elaterium, die Esels- oder Spritzgurke, aus der Familie der Cucurbitaceae, ist seit der Antike im Mittelmeerraum als Arzneipflanze bekannt. Auch heute noch werden Fruchtsaftextrakte in der traditionellen Medizin verschiedener mediterraner Länder eingesetzt, so z.B. bei Sinusitis, Entzündungen, Rheuma, Leberbeschwerden und Gelbsucht. Viele dieser Anwendungsgebiete konnten in pharmakologischen Untersuchungen zumindest in vitro – teilweise auch in vivo, insbesondere bei Sinusitis – bestätigt werden. Phytochemisch wurden zahlreiche Triterpene, vor allem Cucurbitacine, isoliert, die mit der Wirkung in Verbindung gebracht werden.
Summary
Ecballium elaterium (L.) A. Rich. – Portrait of a medicinal plant
Ecballium elaterium, the squirting cucumber, from the Cucurbitaceae family, has been known in the Mediterranean area as a medicinal plant since antiquity. Extracts of the fruit are still used in different folk medicinal systems in the Mediterranean region, especially as a curative agent against sinusitis, inflammation, rheumatism, liver disorders and jaundice. Many of these indications could be confirmed by pharmacological studies at least in vitro, in part also in vivo, e.g. against sinusitis. Phytochemical analyses of the fruit extracts have led to the isolation of several triterpenoids, especially of a series of cucurbitacins, which explain at least in part the pharmacological activities.
Schlüsselwörter
Ecballium elaterium - Spritzgurke - Eselsgurke - Cucurbitaceae - Cucurbitacine - Sinusitis - Entzündungen - Leberbeschwerden
Key words
Ecballium elaterium - squirting cucumber - Cucurbitaceae - cucurbitacins - sinusitis - inflammation - liver disorder
Literatur
- 1
Agil MA, Risco S, Miró M, et al..
Analgesic and antipyretic effects of Ecballium elaterium (L.) A. Richard. extract in rodents.
Phytother Res.
1995;
9
135-138
MissingFormLabel
- 2
Agil A, Miró M, Jiménez J, et al..
Isolation of an anti-hepatotoxic principle from the juice of Ecballium elaterium
.
Planta Med.
1999;
65
673-675
MissingFormLabel
- 3
Alqasoumi SI, Abdel-Kader MS.
Screening of traditional Saudi plants for hepatoprotective effect.
Planta Med.
2008;
74
1139
MissingFormLabel
- 4
Attard E, Scicluna-Spiteri A.
The cultivation and cucurbitacin content of Ecballium elaterium (L.) A. Rich.
CGC Report.
2003;
26
66-69
MissingFormLabel
- 5
Başaran AA, Çakmak EA, Degirmenci T, et al..
Chromosome aberrations induced by aflatoxin B1 in rat bone marrow cells in vivo and
their suppression by Ecballium elaterium
.
Fitoterapia.
1993;
64
310-313
MissingFormLabel
- 6
Başaran AA, Yu T-W, Plewa MJ, Anderson D.
An investigation of some Turkish herbal medicines in Salmonella typhimurium and in the COMET assay in human lymphocytes.
Terat Carc Mutag.
1996;
16
125-138
MissingFormLabel
- 7
Başaran AA, Ceritolu I, Ündeer Ü, Başaran N.
Immunomodulatory activities of some Turkish medicinal plants.
Phytother Res.
1997;
11
609-611
MissingFormLabel
- 8 Besler B. Der Garten von Eichstätt. Nürnberg, 1613. Köln; Taschen 2007 (Nachdruck): Abbildung 284
MissingFormLabel
- 9
Caiozzi GA, Cabrera DT, Mardónez JMU, Saldías FP.
Hierbas medicinales y graves efectos adversos: Angioedema de úvula causado por uso
de Ecballium elaterium
.
Rev Méd Chile.
2002;
130
1407-1410
MissingFormLabel
- 10
Chakravarty AK, Das B, Masuda K, et al..
Triterpenoid glycosides from fruits of Ecballium elaterium
.
J Ind Chem Soc.
1997;
74
858-863
MissingFormLabel
- 11
Chen JC, Chiu MH, Nie RL, et al..
Cucurbitacins and cucurbitane glycosides: structures and biological activities.
Nat Prod Rep.
2005;
22
386-399
MissingFormLabel
- 12 Chinou IB, Roussis V, Vagias C, Roussakis C. Differentiation-inducers from Ecballium elaterium L. on a non-small-cell bronchial carcinoma line. 2000 Years of Natural Products Research
– Past, present and future. Amsterdam; 1999 Abstract 510
MissingFormLabel
- 13 Cogniaux A, Harms H.
Cucurbitaceae, Cucurbitae, Cucumerinae . In: Engler A, Hrsg. Pflanzenreich – Regni vegetabilis conspectus. Leipzig; Verlag von Wilhelm Engelmann 1924: 94-97MissingFormLabel - 14
Costich DE.
Gender specialization across a climatic gradient: Experimental comparison of monoecious
and dioecious Ecballium
.
Ecology.
1995;
76
1036-1050
MissingFormLabel
- 15
El Beyrouthy M, Arnold N, Delelis-Dusollier A, Dupont F.
Plants used as remedies antirheumatic and antineuralgic in the traditional medicine
of Lebanon.
J Ethnopharmacol.
2008;
120
315-334
MissingFormLabel
- 16
Ekící M, Satilmiş A, Ay YD, et al..
Ecballium elaterium (L.) meyvelerinin sinüzite karşi kullanimi.
Ekoloji.
1998;
27
24-25
MissingFormLabel
- 17
Elayan HH, Garaibeh MN, Zmeili SM, Salhab SA.
Effects of Ecballium elaterium juice on serum bilirubin concentrations in male rats.
Int J Crude Drug Res.
1989;
27
227-234
MissingFormLabel
- 18
Fahn A, Shimony C.
Nectary structure and ultrastructure of unisexual flowers of Ecballium elaterium (L.) A. Rich. (Cucurbitaceae) and their presumptive pollinators.
Ann Bot.
2001;
87
27-33
MissingFormLabel
- 19 Fuchs L. New Kreüterbuch. Basel, 1543. Köln; Taschen 2001 (Nachdruck): Kapitel 268
MissingFormLabel
- 20
Greige-Gerges H, Khalil RA, Mansour EA, et al..
Cucurbitacins from Ecballium elaterium juice increase the binding of bilirubin and ibuprofen to albumin in human plasma.
Chem Biol Interact.
2007;
169
53-62
MissingFormLabel
- 21 Hayne FG.
Momordica elaterium . Getreue Darstellung und Beschreibung der in der Arzneykunde gebräuchlichen Gewächse. Berlin; Eigenverlag 1822 Band 8. Kapitel 45MissingFormLabel - 22
Janick J, Paris HS.
The cucurbit images (1515–1518) of the Villa Farnesina, Rome.
Ann Bot.
2006;
97
165-176
MissingFormLabel
- 23
Janick J, Paris HS, Parrish DC.
The cucurbits of Mediterranean antiquity. Identification of taxa from ancient images
and descriptions.
Ann Bot.
2007;
98
1-17
MissingFormLabel
- 24
Kavalci C, Durukan P, Cevik Y, Özer M.
Angioedema due to Ecballium elaterium: Case report.
Akad Acil Tip Derg.
2007;
3
39-40
MissingFormLabel
- 25
Khalil AM, Qaoud KM.
Toxicity and partial characterization of Ecballium elaterium fruit juice.
Pharm Biol.
1993;
31
135-141
MissingFormLabel
- 26
Kloutsos G, Balatsouras DG, Kaberos AC, et al..
Upper airway edema resulting from use of Ecballium elaterium
.
Laryngoscope.
2001;
111
1652-1655
MissingFormLabel
- 27
Köhler H.
Der Fruchtsaft von Momordica elaterium in historischer, chemischer und physiologischer Hinsicht. I. Historischer Theil.
Virchows Arch.
1870;
49
408-434
MissingFormLabel
- 28
Köhler H.
Der Fruchtsaft von Momordica elaterium in historischer, chemischer und physiologischer Hinsicht. II. Chemischer Theil.
Virchows Arch.
1870;
50
273-293
MissingFormLabel
- 29
Kokkonouzis I, Antoniou G, Varvaressos S, et al..
Upper airway edema due to nasal aspiration of undiluted juice of Ecballium elaterium: Report of three cases.
Am J Case Reports.
2008;
9
255-258
MissingFormLabel
- 30
Kültür S.
Medicinal plants used in Kirklareli Province (Turkey).
J Ethnopharmacol.
2007;
111
341-364
MissingFormLabel
- 31
Lavie D, Szinai S.
The constituents of Ecballium elaterium L. II. α-Elaterin.
J Am Chem Soc.
1958;
80
707-710
MissingFormLabel
- 32
Lavie D, Willner D.
The constituents of Ecballium elaterium L. III. Elatericin A and B.
J Am Chem Soc.
1958;
80
710-714
MissingFormLabel
- 33
Lavie D, Willner D.
The constituents of Ecballium elaterium L. XI. Proposed structures for α-Elaterin and its degradation products.
J Am Chem Soc.
1960;
82
1668-1673
MissingFormLabel
- 34
Lavie D, Shvo Y.
The constituents of Ecballium elaterium L. X. Proposed structures for Elatericin A and B.
J Am Chem Soc.
1960;
82
966-970
MissingFormLabel
- 35
Lavie D, Shvo Y, Gottlieb OR, Glotter E.
The constituents of Ecballium elaterium L. XVI. Stereochemical problems in the Cucurbitacins.
J Chem Soc.
1963;
28
1790-1795
MissingFormLabel
- 36 Lazaris D, Chinou I, Roussis V, et al.. Chemical constituents from Ecballium elaterium L. (Cucurbitaceae) and their effect on a non-small-cell bronchial carcinoma line. 45. Jahreskongress der Gesellschaft für Arzneipflanzenforschung, Regensburg 1997 Abstract K09
MissingFormLabel
- 37
Ljubuncic P, Azaizeh H, Portnaya I, et al..
Antioxidant activity and cytotoxicity of eight plants used in traditional Arab medicine
in Israel.
J Ethnopharmacol.
2005;
99
43-47
MissingFormLabel
- 38
Miró M.
Cucurbitacins and their pharmacological effects.
Phytother Res.
1995;
9
159-168
MissingFormLabel
- 39 [Anonymous] .Flora Nordica. Cucurbitaceae: Ecballium A. Rich., nom. cons.
http://www.floranordica.org/Review/-Review_public/accounts/Cucurbitaceae.html; Stand:
02.12.2008
MissingFormLabel
- 40
Panosyan AG, Nikishchenko MN, Avetisyan GM.
Structure of 22-Deoxocucurbitacins isolated form Bryonia alba and Ecballium elaterium
.
Chem Nat Comp.
1986;
21
638-645
MissingFormLabel
- 41
Power FB, Moore CW.
CCXVIII. – The constituents of the fruit of Ecballium elaterium
.
J Chem Soc, Trans.
1909;
95
1985-1993
MissingFormLabel
- 42
Raikhlin-Eisenkraft B, Bentur Y.
Ecballium elaterium (Squirting cucumber) – remedy or poison?.
Clin Toxicol.
2000;
38
305-308
MissingFormLabel
- 43
Rao MM, Meshulam H, Lavie D.
The constituents of Ecballium elaterium L. XXIII. Cucurbitacins and hexanorcucurbitacins.
J Chem Soc, Perkin I.
1974;
22
2552-2556
MissingFormLabel
- 44
Rao MM, Lavie D.
The constituents of Ecballium elaterium L. XXII. Phenolics as minor components.
Tetrahedron.
1974;
30
3309-3313
MissingFormLabel
- 45
Rencüzoullari E, Ila HB, Kayraldiz A, et al..
The mutagenic and antimutagenic effects of Ecballium elaterium fruit juice in human peripheral lymphocytes.
Russ J Genetics.
2006;
42
623-627
MissingFormLabel
- 46 Roth L, Daunderer M, Kormann K. Giftpflanzen – Pflanzengifte. 5. Aufl. Landsberg; Ecomed Verlagsgesellschaft 2008 : 316-317
MissingFormLabel
- 47
Satar S, Gokel Y, Toprak N, Sebe A.
Lifethreatening uvular angioedema caused by Ecballium elaterium
.
Eur J Emerg Med.
2001;
8
337-339
MissingFormLabel
- 48
Seger C, Sturm S, Haslinger E, Stuppner H.
A new Cucurbitacin D related 16,23-epoxy derivative and its isomerization products.
Org Lett.
2004;
6
633-636
MissingFormLabel
- 49
Seger C, Sturm S, Mair ME, et al..
1H and 13C NMR signal assignment of cucurbitacin derivatives from Citrullus colocynthis (L.) Schrader and Ecballium elaterium L. (Cucurbitaceae).
Magn Reson Chem.
2005;
43
489-491
MissingFormLabel
- 50
Seger C, Sturm S, Haslinger E, Stuppner H.
NMR signal assignment of 22-Deoxocucurbitacin D and Cucurbitacin D from Ecballium elaterium L.
(Cucurbitaceae) Monatsh Chem.
2005;
136
1645-1649
MissingFormLabel
- 51
Seifert K, Elgamal MH.
New cucurbitacin glucosides from Ecballium elaterium
.
Pharmazie.
1977;
32
605-606
MissingFormLabel
- 52
Sezik E, Yesilada E.
Clinical effects of the fruit juice of Ecballium elaterium in the treatment of sinusitis.
J Toxicol Clin Toxicol.
1995;
33
381-382
MissingFormLabel
- 53
Uslu C, Karasen RM, Sahin F, et al..
Effect of aqueous extracts of Ecballium elaterium Rich, in the rabbit model of rhinosinusitis.
Int J Ped Otorhingol.
2006;
70
515-518
MissingFormLabel
- 54
Yesilada E, Tanaka S, Sezik E, Tabata M.
Isolation of an anti-inflammatory principle from the fruit juice of Ecballium elaterium
.
J Nat Prod.
1988;
51
504-508
MissingFormLabel
- 55
Yesilada E, Tanaka S, Tabata M, Sezik E.
Antiinflammatory effects of the fruit juice of Ecballium elaterium on edemas in mice.
Phytother Res.
1989;
3
75-76
MissingFormLabel
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