Sinonasal Undifferentiated Carcinoma: A 13-Year Experience at a Single Institution

Erin M Lin; Anthony Sparano; Aaron Spalding; Avraham Eisbruch; Francis P Worden; Jason Heth; Stephen E Sullivan; B. Gregory Thompson; Lawrence J Marentette

doi:10.1055/s-0029-1236165

Skull Base 2010; 20(2): 061-067
DOI: 10.1055/s-0029-1236165

ORIGINAL ARTICLE

Sinonasal Undifferentiated Carcinoma: A 13-Year Experience at a Single Institution

Erin M. Lin¹ , Anthony Sparano² , Aaron Spalding³ , Avraham Eisbruch³ , Francis P. Worden⁴ , Jason Heth⁵ , Stephen E. Sullivan⁵ , B. Gregory Thompson⁵ , Lawrence J. Marentette¹ ^, ⁵

¹Department of Otolaryngology–Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan
²Department of Otolaryngology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, New Brunswick, New Jersey and Coastal Ear Nose and Throat/Facial Plastic and Reconstructive Surgery, Neptune, New Jersey
³Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan
⁴Department of Internal Medicine–Hematology/Oncology, University of Michigan, Ann Arbor, Michigan
⁵Department of Neurosurgery, University of Michigan, Ann Arbor, Michigan

Abstract

ABSTRACT

We present our experience with sinonasal undifferentiated carcinoma at the University of Michigan over 13 years and review prior published data. We conducted a retrospective review of 19 patients who presented to a tertiary care academic center multidisciplinary skull base clinic with sinonasal undifferentiated carcinoma between 1995 and 2008. Overall survival was 22% at 5 years, and the estimated 5-year distant metastasis-free survival was 35%. At 2 years, local control was 83%, regional control was 50%, and distant control was 83%. Local control was best in those patients treated nonsurgically, as was median survival, though this was not statistically significant. Nodal disease in the neck, either at presentation or at recurrence, was noted in 26% of patients. Survival for sinonasal undifferentiated carcinoma remains poor. It is possible that up-front radiation or chemoradiation will lead to better local control rates, though surgery remains a mainstay of treatment. In all cases, the cervical nodes should be addressed with primary treatment.

KEYWORDS

SNUC - sinonasal undifferentiated carcinoma - anterior skull base - subcranial

Full Text

References

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Erin M LinM.D.

Clinical Lecturer, Department of Otolaryngology–Head and Neck Surgery

University of Michigan, 1500 E. Medical Center Drive, Ann Arbor, MI 48109

Email: elmk@med.umich.edu