Semin Neurol 2009; 29(5): 541-547
DOI: 10.1055/s-0029-1241042
© Thieme Medical Publishers

Vestibular Evoked Myogenic Potentials (VEMPs): Usefulness in Clinical Neurotology

Krister Brantberg1 , 2
  • 1Department of Audiology, Karolinska Hospital, Stockholm, Sweden
  • 2Department of Otolaryngology, St. Olavs University Hospital and Norwegian University of Science and Technology, Trondheim, Norway
Further Information

Publication History

Publication Date:
15 October 2009 (online)

ABSTRACT

Testing vestibular evoked myogenic potentials (VEMPs) may be the most important new clinical test for evaluation of vestibular function developed during the past 100 years since the introduction of the caloric test. VEMPs are easily recordable and therefore suitable for everyday testing in clinical neurotology. VEMPs in response to air-conducted sound stimulation using surface electrodes over the sternocleidomastoid muscles reveal saccular function, inferior vestibular nerve function, and vestibulocollic connections. At present, VEMPs are of clinical importance for estimating the severity of peripheral vestibular damage due to different pathophysiologic processes such as Ménière's disease, vestibular neuritis, and vestibular schwannoma. VEMPs can also be used to document vestibular hypersensitivity to sounds (Tullio phenomenon). In addition, VEMP testing constitutes an electrophysiologic method that is able to detect subclinical lesions in central vestibular pathways in patients with multiple sclerosis. In the near future, testing ocular VEMPs (OVEMPs) in response to bone-conducted vibration may prove to be of clinical importance for the evaluation of utricular function.

REFERENCES

  • 1 Bickford R G, Jacobson J L, Cody D T. Nature of average evoked potentials to sound and other stimuli in man.  Ann N Y Acad Sci. 1964;  112 204-223
  • 2 Colebatch J G, Halmagyi G M, Skuse N F. Myogenic potentials generated by a click-evoked vestibulocollic reflex.  J Neurol Neurosurg Psychiatry. 1994;  57(2) 190-197
  • 3 Bath A P, Harris N, McEwan J, Yardley M P. Effect of conductive hearing loss on the vestibulo-collic reflex.  Clin Otolaryngol Allied Sci. 1999;  24(3) 181-183
  • 4 Welgampola M S, Colebatch J G. Vestibulocollic reflexes: normal values and the effect of age.  Clin Neurophysiol. 2001;  112(11) 1971-1979
  • 5 Colebatch J G, Rothwell J C. Motor unit excitability changes mediating vestibulocollic reflexes in the sternocleidomastoid muscle.  Clin Neurophysiol. 2004;  115(11) 2567-2573
  • 6 Uchino Y, Sato H, Sasaki M et al.. Sacculocollic reflex arcs in cats.  J Neurophysiol. 1997;  77(6) 3003-3012
  • 7 Kuo S W, Yang T H, Young Y H. Changes in vestibular evoked myogenic potentials after Meniere attacks.  Ann Otol Rhinol Laryngol. 2005;  114(9) 717-721
  • 8 Young Y H, Wu C C, Wu C H. Augmentation of vestibular evoked myogenic potentials: an indication for distended saccular hydrops.  Laryngoscope. 2002;  112(3) 509-512
  • 9 de Waele C, Huy P T, Diard J P, Freyss G, Vidal P P. Saccular dysfunction in Meniere's disease.  Am J Otol. 1999;  20(2) 223-232
  • 10 Murofushi T, Shimizu K, Takegoshi H, Cheng P W. Diagnostic value of prolonged latencies in the vestibular evoked myogenic potential.  Arch Otolaryngol Head Neck Surg. 2001;  127(9) 1069-1072
  • 11 De Waele C, Meguenni R, Freyss G et al.. Intratympanic gentamicin injections for Meniere disease: vestibular hair cell impairment and regeneration.  Neurology. 2002;  59(9) 1442-1444
  • 12 Helling K, Schönfeld U, Clarke A H. Treatment of Ménière's disease by low-dosage intratympanic gentamicin application: effect on otolith function.  Laryngoscope. 2007;  117(12) 2244-2250
  • 13 Murofushi T, Matsuzaki M, Takegoshi H. Glycerol affects vestibular evoked myogenic potentials in Meniere's disease.  Auris Nasus Larynx. 2001;  28(3) 205-208
  • 14 Seo T, Node M, Yukimasa A, Sakagami M. Furosemide loading vestibular evoked myogenic potential for unilateral Ménière's disease.  Otol Neurotol. 2003;  24(2) 283-288
  • 15 Rauch S D, Zhou G, Kujawa S G, Guinan J J, Herrmann B S. Vestibular evoked myogenic potentials show altered tuning in patients with Ménière's disease.  Otol Neurotol. 2004;  25(3) 333-338
  • 16 Thomas K, Harrison M S. Long-term follow up of 610 cases of Ménière's disease.  Proc R Soc Med. 1971;  64(8) 853-857
  • 17 Lin M Y, Timmer F C, Oriel B S et al.. Vestibular evoked myogenic potentials (VEMP) can detect asymptomatic saccular hydrops.  Laryngoscope. 2006;  116(6) 987-992
  • 18 Colebatch J G, Day B L, Bronstein A M et al.. Vestibular hypersensitivity to clicks is characteristic of the Tullio phenomenon.  J Neurol Neurosurg Psychiatry. 1998;  65(5) 670-678
  • 19 Brantberg K, Bergenius J, Tribukait A. Vestibular-evoked myogenic potentials in patients with dehiscence of the superior semicircular canal.  Acta Otolaryngol. 1999;  119(6) 633-640
  • 20 Watson S RD, Halmagyi G M, Colebatch J G. Vestibular hypersensitivity to sound (Tullio phenomenon): structural and functional assessment.  Neurology. 2000;  54(3) 722-728
  • 21 Brantberg K, Verrecchia L. Testing vestibular-evoked myogenic potentials with 90-dB clicks is effective in the diagnosis of superior canal dehiscence syndrome.  Audiol Neurootol. 2009;  14(1) 54-58
  • 22 Welgampola M S, Myrie O A, Minor L B, Carey J P. Vestibular-evoked myogenic potential thresholds normalize on plugging superior canal dehiscence.  Neurology. 2008;  70(6) 464-472
  • 23 Büchele W, Brandt T. Vestibular neuritis—a horizontal semicircular canal paresis?.  Adv Otorhinolaryngol. 1988;  42 157-161
  • 24 Fetter M, Dichgans J. Vestibular neuritis spares the inferior division of the vestibular nerve.  Brain. 1996;  119(Pt 3) 755-763
  • 25 Aw S T, Fetter M, Cremer P D, Karlberg M, Halmagyi G M. Individual semicircular canal function in superior and inferior vestibular neuritis.  Neurology. 2001;  57(5) 768-774
  • 26 Murofushi T, Halmagyi G M, Yavor R A, Colebatch J G. Absent vestibular evoked myogenic potentials in vestibular neurolabyrinthitis. An indicator of inferior vestibular nerve involvement?.  Arch Otolaryngol Head Neck Surg. 1996;  122(8) 845-848
  • 27 Kim H A, Hong J H, Lee H et al.. Otolith dysfunction in vestibular neuritis: recovery pattern and a predictor of symptom recovery.  Neurology. 2008;  70(6) 449-453
  • 28 Murofushi T, Monobe H, Ochiai A, Ozeki H. The site of lesion in “vestibular neuritis”: study by galvanic VEMP.  Neurology. 2003;  61(3) 417-418
  • 29 Murofushi T, Iwasaki S, Ushio M. Recovery of vestibular evoked myogenic potentials after a vertigo attack due to vestibular neuritis.  Acta Otolaryngol. 2006;  126(4) 364-367
  • 30 Ushio M, Matsuzaki M, Takegoshi H, Murofushi T. Click- and short tone burst-evoked myogenic potentials in cerebellopontine angle tumors.  Acta Otolaryngol Suppl. 2001;  545 133-135
  • 31 Patko T, Vidal P P, Vibert N, Tran Ba Huy P, de Waele C. Vestibular evoked myogenic potentials in patients suffering from an unilateral acoustic neuroma: a study of 170 patients.  Clin Neurophysiol. 2003;  114(7) 1344-1350
  • 32 Suzuki M, Yamada C, Inoue R, Kashio A, Saito Y, Nakanishi W. Analysis of vestibular testing in patients with vestibular schwannoma based on the nerve of origin, the localization, and the size of the tumor.  Otol Neurotol. 2008;  29(7) 1029-1033
  • 33 Ushio M, Iwasaki S, Chihara Y et al.. Is the nerve origin of the vestibular schwannoma correlated with vestibular evoked myogenic potential, caloric test, and auditory brainstem response?.  Acta Otolaryngol. 2008;  , November 26 (Epub ahead of print)
  • 34 Tsutsumi T, Komatsuzaki A, Noguchi Y, Tokano H, Kitamura K. Postoperative vestibular-evoked myogenic potentials in cases with vestibular schwannomas.  Acta Otolaryngol. 2001;  121(4) 490-493
  • 35 Patkó T, Simó M, Arányi Z. Vestibular click-evoked myogenic potentials: sensitivity and factors determining abnormality in patients with multiple sclerosis.  Mult Scler. 2007;  13(2) 193-198
  • 36 Versino M, Colnaghi S, Callieco R, Bergamaschi R, Romani A, Cosi V. Vestibular evoked myogenic potentials in multiple sclerosis patients.  Clin Neurophysiol. 2002;  113(9) 1464-1469
  • 37 Sartucci F, Logi F. Vestibular-evoked myogenic potentials: a method to assess vestibulo-spinal conduction in multiple sclerosis patients.  Brain Res Bull. 2002;  59(1) 59-63
  • 38 Bandini F, Beronio A, Ghiglione E, Solaro C, Parodi R C, Mazzella L. The diagnostic value of vestibular evoked myogenic potentials in multiple sclerosis.  J Neurol. 2004;  251(5) 617-621
  • 39 Todd N P, Rosengren S M, Aw S T, Colebatch J G. Ocular vestibular evoked myogenic potentials (OVEMPs) produced by air- and bone-conducted sound.  Clin Neurophysiol. 2007;  118(2) 381-390
  • 40 Rosengren S M, Aw S T, Halmagyi G M, Todd N P, Colebatch J G. Ocular vestibular evoked myogenic potentials in superior canal dehiscence.  J Neurol Neurosurg Psychiatry. 2008;  79(5) 559-568
  • 41 Curthoys I S, Kim J, McPhedran S K, Camp A J. Bone conducted vibration selectively activates irregular primary otolithic vestibular neurons in the guinea pig.  Exp Brain Res. 2006;  175(2) 256-267
  • 42 Isu N, Graf W, Sato H et al.. Sacculo-ocular reflex connectivity in cats.  Exp Brain Res. 2000;  131(3) 262-268
  • 43 Iwasaki S, Chihara Y, Smulders Y E et al.. The role of the superior vestibular nerve in generating ocular vestibular-evoked myogenic potentials to bone conducted vibration at Fz.  Clin Neurophysiol. 2009;  120(3) 588-593
  • 44 Todd N P, Rosengren S M, Colebatch J G. A utricular origin of frequency tuning to low-frequency vibration in the human vestibular system?.  Neurosci Lett. 2009;  451(3) 175-180

Krister BrantbergM.D. Ph.D. 

Department of Audiology, Karolinska Hospital

SE-171 76 Stockholm, Sweden

Email: krister.brantberg@karolinska.se

    >