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Aktuelle Neurologie 2010; 37(6): 292-303
DOI: 10.1055/s-0030-1248564
DOI: 10.1055/s-0030-1248564
Fort- und Weiterbildung
© Georg Thieme Verlag KG Stuttgart · New York
Kinderwunsch und Multiple Sklerose
Family Planning and Multiple SclerosisFurther Information
Publication History
Publication Date:
03 September 2010 (online)
Lernziele
Kenntnisse über beidseitige Wechselwirkung von Multiple(r) Sklerose und Schwangerschaft Kenntnisse über aktuelle Datenlage zur immunmodulatorischen Therapie für MS-Patienten mit Kinderwunsch Therapiemöglichkeiten post partum
Literatur
- 1 Hellwig K, Brune N, Haghikia A. et al . Reproductive counselling, treatment and course of pregnancy in 73 German MS patients. Acta Neurol Scand. 2008; 118 24-28
- 2 Vukusic S, Hutchinson M, Hours M. The Pregnancy In Multiple Sclerosis Group, Pregnancy In Multiple Sclerosis Group et al . Pregnancy and multiple sclerosis (the PRIMS study): clinical predictors of post-partum relapse. Brain. 2004; 127 1353-1360
- 3 Park-Wyllie L, Mazzotta P, Pastuzak A. et al . Birth defects after maternal exposure to corticosteroids: prospective cohort study and meta-analysis of epidemiological studies. Teratology. 2000; 62 385-392
- 4 Hoffmann L A, Kumpfel T, Heer I. et al . [Pregnancy and immunomodulatory therapy in multiple sclerosis patients]. Nervenarzt. 2006; 77 663-668
- 5 Koch M, Uyttenboogaart M, Heersema D. et al . Parity and secondary progression in multiple sclerosis. J Neurol Neurosurg Psychiatry. 2009; 80 676-678
- 6 D’hooghe M B, Nagels G, Uitdehaag B M. Long-term effects of childbirth in MS. J Neurol Neurosurg Psychiatry. 2010; 81 38-41
- 7 Wegmann T G, Lin H, Guilbert L. et al . Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon?. Immunol Today. 1993; 14 353-356
- 8 Sánchez-Ramón S, Navarro A J, Aristimuño C. et al . Pregnancy-induced expansion of regulatory T-lymphocytes may mediate protection to multiple sclerosis activity. Immunol Lett. 2005; 96 195-201
- 9 Airas L, Saraste M, Rinta S. et al, Finnish Multiple Sclerosis and Pregnancy Study Group . Immunoregulatory factors in multiple sclerosis patients during and after pregnancy: relevance of natural killer cells. Clin Exp Immunol. 2008; 151 235-243
- 10 Airas L, Nikula T, Huang Y H. et al . Postpartum-activation of multiple sclerosis is associated with down-regulation of tolerogenic HLA-G. J Neuroimmunol. 2007; 187 205-211
- 11 Doria A, Iaccarino L, Arienti S. et al . Th2 immune deviation induced by pregnancy: the two faces of autoimmune rheumatic diseases. Reprod Toxicol. 2006; 22 234-241
- 12 Vukusic S, Ionescu I, El-Etr M. et al, Prevention of Post-Partum Relapses with Progestin and Estradiol in Multiple Sclerosis Study Group . The Prevention of Post-Partum Relapses with Progestin and Estradiol in Multiple Sclerosis (POPART’MUS) trial: rationale, objectives and state of advancement. J Neurol Sci 2009. 15; 286 114-118
- 13 Cocco E, Sardu C, Gallo P. et al, the FEMIMS group* . Frequency and risk factors of mitoxantrone-induced amenorrhea in multiple sclerosis: the FEMIMS study. Mult Scler. 2008; 14 1225-1233
- 14 Katsifis G E, Tzioufas A G. Ovarian failure in systemic lupus erythematosus patients treated with pulsed intravenous cyclophosphamide. Lupus. 2004; 13 673-678
- 15 Kelly V M, Nelson L M, Chakravarty E F. Obstetric outcomes in women with multiple sclerosis and epilepsy. Neurology. 2009; 73 1831-1836
- 16 Dahl J, Myhr K M, Daltveit A K. et al . Pregnancy, delivery, and birth outcome in women with multiple sclerosis. Neurology. 2005; 65 1961-1963
- 17 Dahl J, Myhr K M, Daltveit A K. et al . Pregnancy, delivery and birth outcome in different stages of maternal multiple sclerosis. J Neurol. 2008; 255 623-627
- 18 Scott J R. Risks to the children born to mothers with autoimmune diseases. Lupus. 2002; 11 655-660
- 19 Boskovic R, Wide R, Wolpin J. et al . The reproductive effects of beta interferon therapy in pregnancy: a longitudinal cohort. Neurology. 2005; 65 807-811
- 20 Patti F, Cavallaro T, Lo Fermo S. et al . Is in utero early-exposure to interferon beta a risk factor for pregnancy outcomes in multiple sclerosis?. J Neurol. 2008; 255 1250-1253
- 21 Weber-Schoendorfer C, Schaefer C. Multiple sclerosis, immunomodulators, and pregnancy outcome: a prospective observational study. Mult Scler. 2009; 15 1037-1042
- 22 Coyle P K, Christie S, Fodor P. et al . Multiple sclerosis gender issues: clinical practices of women neurologists. Mult Scler. 2004; 10 582-588
- 23 Sandberg-Wollheim M, Frank D, Goodwin T M. et al . Pregnancy outcomes during treatment with interferon beta-1a in patients with multiple sclerosis. Neurology. 2005; 65 802-806
- 24 de Santis M, Straface G, Cavaliere A F. et al . The first case of mitoxantron exposure in early pregnancy. Neuro Toxicology. 2007; 28 696-697
- 25 Briggs G G, Freemann R K, Yaffe S J. Classification of drugs for teratogenic risk: an anachronistic way of counselling: a reply to Merlob and Stahl. Birth defects Res A. 2003; 67 207-208
- 26 Hellwig K, Agne H, Gold R. Interferon beta, birth weight and pregnancy in multiple sclerosis. J Neurol. 2009; 256 830-831
- 27 Gucev Z S, Kirovski I, Jancevska A. et al . Papillorenal syndrome after Beta-interferon treatment in pregnancy. Ren Fail. 2009; 31 602-605
- 28 Sandberg-Wollheim M, Alteri E, Stam Moraga M. et al . Subcutanous interferon beta 1-a treatment and pregnancy outcomes in patients with MS. Neurology. 2010; 74 (Suppl. 2) 9 S.40.005
- 29 Coyle P K, Johnson K, Pardo L. et al . Pregnancy outcomes in patients with multiple sclerosis treated with glatiramer acetate (Copaxone). Neurology. 2003; 60 A60
- 30 Polman C H, O’Connor P W, Havrdova E. et al, AFFIRM Investigators . A randomized placebo controlled trial of natalizumab for relapsing remitting multiple sclerosis. N Engl J Med. 2006; 354 899-910
- 31 Hellwig K, Haghikia A, Gold R. Motherhood and Natalizumab-effects of natalizumab therapy on pregnancy outcome and disease activity during pregnancy. Neurology. 2010; 74 (Suppl. 2) 9 P 06.168
- 32 Azuno Y, Kaku K, Fujita N. Mitoxantron and etoposid in breastmilk. Am J Hematol. 1995; 48 131-132
- 33 Giacalone P L, Benos P, Rousseau O. Chemotherapy for breast carcinoma during pregnancy. Cancer. 1999; 86 2266-2272
- 34 Reynoso E E, Huerta F. Acute leukemia and pregnancy – fatal fetal outcome after exposure to idarubicin during the second trimester. Acta Oncol. 1994; 33 703-716
- 35 Blumenfeld Z, Shapiro D, Shteinberg M. et al . Preservation of fertility and ovarian function and minimizing gonadotoxicity in young women with systemic lupus erythematosus treated by chemotherapy. Lupus. 2000; 9 401-405
- 36 Telez N, Gris J, Tintore M. et al . Prevention of persistent ovarian failure after mitoxantrone in women with MS. Design of a treatment protocol with triptorelin. Multiple sclerosis. 2006; 12 (Suppl. 1) P 758
- 37 Thomas W. Hale, Medication and Mothers Milk, 13th edition. Hale Publishing 2006: Seite 437 und 504
- 38 Kumar A R, Hale T W, Mock R E. Transfer of interferon alfa into human breast milk. J Hum Lact. 2000; 16 226-228
- 39 Azuno Y, Kaku K, Fujita N. et al . Mitoxantrone and etoposide in breast milk. Am J Hematol. 1995; 48 131-132
- 40 De Seze J, Chapelotte M, Delalande S. et al . Intravenous corticosteroids in the postpartum period for reduction of acute exacerbations in multiple sclerosis. Mult Scler. 2004; 10 596-597
- 41 Achiron A, Kishner I, Dolev M. et al . Effect of intravenous immunoglobulin treatment on pregnancy and postpartum-related relapses in multiple sclerosis. J Neurol. 2004; 251 1133-1137
- 42 Haas J, Hommes O R. A dose comparison study of IVIG in postpartum relapsing-remitting multiple sclerosis. Mult Scler. 2007; 13 900-908
- 43 Hellwig K, Beste C, Schimrigk S. et al . Immunomodulation and postpartum relapses in patients with multiple sclerosis. Ther Adv Neurol Dis. 2009; 2 7-11
- 44 Gold R, Stangel M, Dalakas M C. Drug Insight: The use of intravenous immunoglobulin in neurology-therapeutic considerations and practical issues. Nat Clin Pract Neurol. 2007; 3 36-44
- 45 Langer-Gould A, Huang S M, Gupta R. et al . Exclusive breastfeeding and the risk of postpartum relapses in women with multiple sclerosis. Arch Neurol. 2009; 66 958-963
- 46 Langer-Gould A, Gupta R, Huang S. et al . Interferon-gamma-producing T cells, pregnancy, and postpartum relapses of multiple sclerosis. Arch Neurol. 2010; 67 51-57
- 47 Hellwig K, Haghikia A, Agne H. et al . Protective effect of breastfeeding in postpartum relapse rate of mothers with Multiple Sclerosis. Arch Neurol. 2009; 66 1580-1581
- 48 Portaccio E, Ghezzi A, Hakiki B. et al . Breastfeeding is not related with the risk of postpartum relapses in women with multiple sclerosis. Neurology. 2010; 74 (Suppl. 2) S40.003
- 49 Greenberger P A, Odeh Y K, Frederiksen M C. et al . Pharmacokinetics of prednisolone transfer to breast milk. Clin Pharmacol Ther. 1993; 53 324-328
- 50 Laplaud D A, Leray E, Barriere P. et al . Increase in multiple sclerosis relapse rate following in vitro fertilization. Neurology. 2006; 66 1280-1281
- 51 Hellwig K, Beste C, Brune N. et al . Increased MS relapse rate during assisted reproduction technique. J Neurol. 2008; 255 592-593
- 52 Hellwig K, Schimrigk S, Beste C. et al . Increase of relapse rate during assisted reproduction technique in patients with multiple sclerosis. Eur Neurol. 2008; 61 65-68
- 53 Buljevac D, Hop W C, Reedeker W. et al . Self reported stressful life events and exacerbations in multiple sclerosis: a prospective study. BMJ. 2003; 327 646
- 54 Hellwig K, Haghikia A, Gold R. Parenthood and immunomodulation in patients with multiple sclerosis. J Neurol. 2009; 257 580-583
Dr. Kerstin Hellwig
Neurologische Klinik
St. Josef Hospital
Ruhr Universität Bochum
Gudrunstr. 56
44791 Bochum
Email: k.hellwig@klinikum-bochum.de