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Planta Med 2010; 76(15): 1691-1693
DOI: 10.1055/s-0030-1249782
Pharmacology
Letters
© Georg Thieme Verlag KG Stuttgart · New York

Inhibition of Aldose Reductase In Vitro by Constituents of Ganoderma lucidum

Sri Fatmawati1 , 2 , Kuniyoshi Shimizu1 , Ryuichiro Kondo1
  • 1Department of Forest and Forest Products Sciences, Faculty of Agriculture, Kyushu University, Fukuoka, Japan
  • 2Department of Chemistry, Faculty of Mathematics and Natural Sciences, Sepuluh Nopember Institute of Technology, Kampus ITS-Sukolilo, Surabaya, Indonesia
Further Information

Publication History

received November 10, 2009 revised March 8, 2010

accepted March 9, 2010

Publication Date:
08 April 2010 (online)

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Abstract

CHCl3 extract of the fruiting body of Ganoderma lucidum was found to show inhibitory activity on human aldose reductase in vitro. From the acidic fraction, potent human aldose reductase inhibitors, ganoderic acid C2 (1) and ganoderenic acid A (2), were isolated together with three related compounds. It was found that the free carboxyl group of ganoderic acid C2 and ganoderenic acid A is essential in eliciting the inhibitory activity considering the much lower activity of their methyl esters.

Key words

Ganoderma lucidum - Ganodermataceae - aldose reductase inhibitor - ganoderic acid - triterpenoid

References

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Prof. Ryuichiro Kondo

Department of Forest and Forest Products Sciences
Faculty of Agriculture
Kyushu University

6-10-1 Hakozaki, Higashi-ku

Fukuoka 812–8581

Japan

Phone: + 81 9 26 42 28 11

Fax: + 81 9 26 42 28 11

Email: ryukondo@agr.kyushu-u.ac.jp

    www.thieme-connect.de/ejournals/toc/plantamedica