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DOI: 10.1055/s-0030-1249972
© Georg Thieme Verlag KG Stuttgart · New York
New Cytotoxic Tetrahydroprotoberberine-Aporphine Dimeric and Aporphine Alkaloids from Corydalis turtschaninovii
Publikationsverlauf
received January 27, 2010
revised March 27, 2010
accepted April 16, 2010
Publikationsdatum:
27. Mai 2010 (online)
![](https://www.thieme-connect.de/media/plantamedica/201015/lookinside/thumbnails/10.1055-s-0030-1249972-1.jpg)
Abstract
Two new tetrahydroprotoberberine-aporphine dimeric alkaloids, corydaturtschines A (1) and B (2), and a new aporphine derivative, ethyl glausuccinate (3), together with 13 known protoberberine (4–16) and nine known aporphine alkaloids (17–25), were isolated from the tubers of Corydalis turtschaninovii. The structures of these new compounds were determined through spectral analyses, including extensive 2D‐NMR data. The absolute configurations of the compounds were clarified by CD spectroscopic studies. The isolated compounds were tested for their cytotoxicity against four human cancer cell lines in vitro using a sulforhodamine B bioassay.
Key words
Corydalis turtschaninovii - Papaveraceae - tetrahydroprotoberberine‐aporphine dimmer - aporphine - cytotoxicity
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Prof. Dr. Kang Ro Lee
Natural Products Laboratory
School of Pharmacy
Sungkyunkwan University
300 Chunchun-dong
Jangan-ku, Suwon 440–746
Korea
Telefon: + 82 3 12 90 77 10
Fax: + 82 3 12 90 77 30
eMail: krlee@skku.ac.kr