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Planta Med 2010; 76(15): 1732-1738
DOI: 10.1055/s-0030-1249972
Natural Product Chemistry
Original Papers
© Georg Thieme Verlag KG Stuttgart · New York

New Cytotoxic Tetrahydroprotoberberine-Aporphine Dimeric and Aporphine Alkaloids from Corydalis turtschaninovii

Ki Hyun Kim1 , Cheng Jie Piao1 , Sang Un Choi2 , Mi Won Son3 , Kang Ro Lee1
  • 1Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, Suwon, Korea
  • 2Korea Research Institute of Chemical Technology, Teajeon, Korea
  • 3Dong-A Pharm Institute, Kiheung, Youngin, Korea
Further Information

Publication History

received January 27, 2010 revised March 27, 2010

accepted April 16, 2010

Publication Date:
27 May 2010 (online)

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Abstract

Two new tetrahydroprotoberberine-aporphine dimeric alkaloids, corydaturtschines A (1) and B (2), and a new aporphine derivative, ethyl glausuccinate (3), together with 13 known protoberberine (4–16) and nine known aporphine alkaloids (17–25), were isolated from the tubers of Corydalis turtschaninovii. The structures of these new compounds were determined through spectral analyses, including extensive 2D‐NMR data. The absolute configurations of the compounds were clarified by CD spectroscopic studies. The isolated compounds were tested for their cytotoxicity against four human cancer cell lines in vitro using a sulforhodamine B bioassay.

Key words

Corydalis turtschaninovii - Papaveraceae - tetrahydroprotoberberine‐aporphine dimmer - aporphine - cytotoxicity

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Prof. Dr. Kang Ro Lee

Natural Products Laboratory
School of Pharmacy
Sungkyunkwan University

300 Chunchun-dong

Jangan-ku, Suwon 440–746

Korea

Phone: + 82 3 12 90 77 10

Fax: + 82 3 12 90 77 30

Email: krlee@skku.ac.kr