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DOI: 10.1055/s-0030-1250046
© Georg Thieme Verlag KG Stuttgart · New York
Growth Inhibitory Activity of Extracted Material and Isolated Compounds from the Fruits of Kigelia pinnata
Publikationsverlauf
received Dec. 11, 2009
revised April 14, 2010
accepted May 18, 2010
Publikationsdatum:
17. Juni 2010 (online)
![](https://www.thieme-connect.de/media/plantamedica/201016/lookinside/thumbnails/10.1055-s-0030-1250046-1.jpg)
Abstract
A study of the components of the fruits of Kigelia pinnata was undertaken to identify compounds with potential growth inhibitory activity against human melanoma cells, since extracts from the fruits of this plant have been described in traditional medicine to have application in the treatment of skin cancer and other skin ailments. A bioactivity-guided fractionation process yielded a number of crude fractions, which demonstrated cytotoxicity in vitro against human melanoma cells. Compounds isolated and identified included the isocoumarins, demethylkigelin (1) and kigelin (2), fatty acids, oleic (3) and heneicosanoic acids (4), the furonaphthoquinone, 2-(1-hydroxyethyl)-naphtho[2,3-b]furan-4,9-dione (5), and ferulic acid (6). A number of structurally related synthetic compounds were also tested using the MTT assay. The most potent series of these compounds, the furonaphthoquinones, also demonstrated a cytotoxic effect in two human breast cancer cell lines tested.
Key words
Kigelia pinnata - Bignoniaceae - MTT assay - melanoma - isocoumarins - furonaphthoquinones
- Supporting Information for this article is available online at
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