Antiplasmodial Constituents from the Fruit Pericarp of Pentadesma butyracea

Bruno Ndjakou Lenta; Louis Marie Kamdem; Silvère Ngouela; Ferdinand Tantangmo; Krishna Prasad Devkota; Fabrice Fekam Boyom; Philip John Rosenthal; Etienne Tsamo

doi:10.1055/s-0030-1250384

Planta Medica, Table of Contents

Planta Med 2011; 77(4): 377-379
DOI: 10.1055/s-0030-1250384

Natural Product Chemistry

Letters
© Georg Thieme Verlag KG Stuttgart · New York

Antiplasmodial Constituents from the Fruit Pericarp of Pentadesma butyracea

Bruno Ndjakou Lenta¹ , Louis Marie Kamdem² , Silvère Ngouela² , Ferdinand Tantangmo² , Krishna Prasad Devkota³ , Fabrice Fekam Boyom⁴ , Philip John Rosenthal⁵ , Etienne Tsamo²

¹Department of Chemistry, Higher Teachers' Training College, University of Yaoundé 1, Yaoundé, Cameroon
²Department of Organic Chemistry, Faculty of Science, TWAS Research Unit, University of Yaoundé 1, Yaoundé, Cameroon
³Department of Chemistry, Organic and Bioorganic Chemistry, Bielefeld University, Bielefeld, Germany
⁴Department of Biochemistry, University of Yaoundé 1, Faculty of Science, Yaoundé, Cameroon
⁵Division of Infectious Diseases, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA

Abstract

Bioassay-guided fractionation of the fruit pericarp of Pentadesma butyracea, using the antiplasmodial test, led to the isolation of a new xanthone, named pentadexanthone (1), together with six known compounds: cratoxylone (2), α-mangostin (3), 1,3,5-trihydroxy-2-methoxyxanthone (4), garcinone E (5), (−)-epicathechin (6), and lupeol (7). The structure of 1 was elucidated by spectroscopic data analysis. An antiplasmodial assay was performed with the isolates, in which compounds 1–3 and 5 exhibited potent activity in vitro against Plasmodium falciparum chloroquine-resistant strain W2, with IC₅₀ values below 3 µM.

Key words

Clusiaceae - Pentadesma butyracea - prenylated xanthones - pentadexanthone - Plasmodium falciparum - antiplasmodial activity

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References

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Dr. Bruno Ndjakou Lenta

Department of Chemistry
Higher Teachers' Training College
University of Yaoundé 1

P. O. Box 47

237 Yaoundé

Cameroon

Phone: +23 7 75 09 75 61

Email: lentabruno@yahoo.fr

Supplementary Material

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