Antiplasmodial Constituents from the Fruit Pericarp of Pentadesma butyracea

Abstract

Bioassay-guided fractionation of the fruit pericarp of Pentadesma butyracea, using the antiplasmodial test, led to the isolation of a new xanthone, named pentadexanthone (1), together with six known compounds: cratoxylone (2), α-mangostin (3), 1,3,5-trihydroxy-2-methoxyxanthone (4), garcinone E (5), (−)-epicathechin (6), and lupeol (7). The structure of 1 was elucidated by spectroscopic data analysis. An antiplasmodial assay was performed with the isolates, in which compounds 1–3 and 5 exhibited potent activity in vitro against Plasmodium falciparum chloroquine-resistant strain W2, with IC₅₀ values below 3 µM.

Key words

Clusiaceae - Pentadesma butyracea - prenylated xanthones - pentadexanthone - Plasmodium falciparum - antiplasmodial activity

References

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