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DOI: 10.1055/s-0030-1258020
Bromotrichloromethane
Publikationsverlauf
Publikationsdatum:
16. August 2010 (online)
Introduction
Readily synthesized by Meunier et al. [¹] in 1938, bromotrichloromethane (BrCCl3) is a reagent of choice in organic synthesis. In recent years, many applications of this reagent have been reported. It can be used to synthesize esters, oxidize heterocycles, allow alkoxyl ring-closure reactions, perform α-bromination of sulfones, achieve radical addition on alkenes and radical cyclization of 1,6-dienes or synthesize dichloroalkenes. Some of these reactions were used at a final stage of complex total syntheses. Moreover, bromotrichloromethane is cheap, commercially available and stable at room temperature without any observed decomposition.
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