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Synthesis 2010(17): 2969-2978
DOI: 10.1055/s-0030-1258165
DOI: 10.1055/s-0030-1258165
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
Furan Ring Opening-Pyrrole Ring Closure: Simple Route to 5-Alkyl-2-(aminomethyl)pyrroles
Further Information
Received
20 April 2010
Publication Date:
12 July 2010 (online)
Publication History
Publication Date:
12 July 2010 (online)
![](https://www.thieme-connect.de/media/synthesis/201017/lookinside/thumbnails/10.1055-s-0030-1258165-1.jpg)
Abstract
A simple route to 5-alkyl-2-(aminomethyl)pyrroles is proposed that is based on hydrolytic ring opening of 5-alkylfurfurylamines followed by pyrrole ring closure under Paal-Knorr conditions.
Key words
furans - ring opening - ring closure - pyrroles - polycycles
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