Abstract
A new synthetic approach to the precursor of the hypoxia marker [¹8 F]-FMISO
has been developed. Three different tosylation methods were studied
for the preparation of the key intermediate. The overall yield is
markedly higher than the yields reported for previous syntheses.
The precursor was used to prepare [¹8 F]-FMISO and
the results were comparable to those obtained when a commercial
precursor was used.
Key words
[¹8 F]-FMISO - hypoxia - radiopharmaceutical - regioselective tosylation
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