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DOI: 10.1055/s-0030-1258486
Enzymatic Oxidative Cyclisation Reactions Leading to Dibenzoazocanes
Publikationsverlauf
Publikationsdatum:
09. Juli 2010 (online)
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Abstract
From simple N-isovanillyltyramine derivatives double oxidative biotransformations can be achieved using tyrosinase leading to the corresponding hydroxylated dibenzoazocanes.
Key words
enzymes - oxidation - biotransformation - heterocycles
- Supporting Information for this article is available online:
- Supporting Information
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References and Notes
Preparation data X-ray structure file reference: CCDC 770222. See Supporting Information for full experimental details and characterisation.
12Alumina (neutral and basic) and Florisil were also used as well as several basic ion exchange resins with a catch and release procedure although these showed no benefits in terms of isolated yield or purities.
13Preparation data X-ray structure file reference: CCDC 770223. See Supporting Information for full experimental details and characterisation.
17Cresolase activity is the hydroxylation of phenols while catecholase is reserved for the oxidation of catechols.