Nef-Perkow Access
to Indolizine Derivatives

Didier Coffinier; Laurent El Kaim; Laurence Grimaud

doi:10.1055/s-0030-1258569

LETTER

Nef-Perkow Access to Indolizine Derivatives

Didier Coffinier*, Laurent El Kaim*, Laurence Grimaud*
Laboratoire Chimie et Procédés, Ecole Nationale Supérieure de Techniques Avancées, 32 Bd Victor, 75739 Paris Cedex 15, France
Fax: +33(1)45525587; e-Mail: didier.coffinier@laposte.net; e-Mail: laurent.elkaim@ensta.fr; e-Mail: laurence.grimaud@ensta.fr;

Abstract

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Abstract

We present herein a new access to indolizine derivatives involving 1,3-dipolar cycloaddition of pyridinium ylides with phosphorylated hydroxyketenimines. These ketenimines are easily formed via a Nef-Perkow cascade involving isocyanides as starting material.

Key words

Nef reaction - isocyanide - indolizine - pyridinium ylide - cycloaddition

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