Synthetic Applications of Diethyl Ethoxymethylenemalonate

Introduction

Diethyl ethoxymethylenemalonate (EMME, Figure  [¹] ), a liquid with a boiling point of 279-281 ˚C, is a very versatile reagent, extensively used for the synthesis of heterocyclic systems. The main application of this reagent is its use in the Gould-Jacobs reaction.

Figure 1 EMME

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