Synlett 2010(17): 2583-2588  
DOI: 10.1055/s-0030-1258777
LETTER
© Georg Thieme Verlag Stuttgart ˙ New York

Morita-Baylis-Hillman Alkylation of Unsaturated Thioesters

Marie E. Krafft*, Kimberly A. Seibert, Thomas F. N. Haxell
Department of Chemistry and Biochemistry, Florida State University, Tallahassee, Fl 32306-4390, USA
Fax: +1(850)6447409; e-Mail: mek@chem.fsu.edu;
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Publikationsverlauf

Received 19 July 2010
Publikationsdatum:
30. September 2010 (online)

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Abstract

The Morita-Baylis-Hillman alkylation reaction with unsaturated thioesters is described. Five- and six-membered rings are formed with ease and in excellent yields. The method is high yielding with either stoichiometric or catalytic amounts of tributylphosphine.