Synlett 2011(1): 73-76  
DOI: 10.1055/s-0030-1259096
LETTER
© Georg Thieme Verlag Stuttgart ˙ New York

Synthetic Studies toward Haouamine B: Construction of Indenotetrahydropyridone Skeleton

Kei-ichiro Okuyama, Yuichi Momoi, Kenji Sugimoto, Kentaro Okano, Hidetoshi Tokuyama*
Graduate School of Pharmaceutical Sciences, Tohoku University, Aramaki, Aoba-ku, 980-8578 Sendai, Japan
Fax: +81(22)7956877; e-Mail: tokuyama@mail.pharm.tohoku.ac.jp;
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Publikationsverlauf

Received 14 October 2010
Publikationsdatum:
14. Dezember 2010 (online)

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Abstract

Synthetic studies on haouamine B are described. The characteristic indenotetrahydropyridone skeleton was constructed by intramolecular Friedel-Crafts alkylation of mesyloxy β-lactam derivative and intramolecular McMurry coupling as key processes.